The effects of infusion of water on renal hemodynamics and the tubular reabsorption of sodium

The Journal of Clinical Investigation
J A Martino, L E EARLEY

Abstract

Anesthetized dogs receiving an infusion of chlorothiazide and ethacrynic acid were given 600-ml infusions of distilled water or dilute dextrose solutions. The absolute rate of tubular sodium reabsorption was depressed, and the glomerular filtration rate was increased during the water loading, despite the associated decreases in plasma sodium concentration and decreases in the filtered load of sodium. The extent to which fractional sodium reabsorption decreased and the excretion of sodium increased was inversely related to the degree to which the filtered load of sodium was depressed as a result of the decreased plasma sodium concentration. We conclude that, in the presence of the diuretic blockade of distal tubular sodium reabsorption, infusion of water depresses proximal tubular reabsorption of sodium and that these changes are qualitatively similar to those previously observed during infusions of saline. Similar depression of tubular reabsorption of sodium and increased excretion of sodium occurred during water loading in the absence of diuretics in dogs undergoing saline diuresis, which presumably provided a high rate of distal sodium reabsorption before water loading. We suggest that volume expansion with water depresses pr...Continue Reading

References

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Citations

Jan 1, 1979·Annals of Biomedical Engineering·N IkedaT Sato
Oct 1, 1970·The American Journal of Medicine·K D Nolph, R W Schrier
Sep 1, 1972·The Journal of Clinical Investigation·E A AlexanderN G Levinsky
Jun 1, 1988·European Journal of Clinical Investigation·W H BoerE J Dorhout Mees
Apr 10, 2015·Journal of the American Society of Nephrology : JASN·Matthew A SparksThomas M Coffman
Nov 1, 1971·The New England Journal of Medicine·R W Schrier, H E De Wardener
Jun 25, 1998·The American Journal of Physiology·K G Franchini

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