The Effects of Inhaled Pimpinella peregrina Essential Oil on Scopolamine-Induced Memory Impairment, Anxiety, and Depression in Laboratory Rats

Molecular Neurobiology
Emel AydinEyup Bagci

Abstract

In the present study, we identified the effects of inhaled Pimpinella peregrina essential oil (1 and 3 %, for 21 continuous days) on scopolamine-induced memory impairment, anxiety, and depression in laboratory rats. Y-maze and radial arm-maze tests were used for assessing memory processes. Also, the anxiety and depressive responses were studied by means of the elevated plus-maze and forced swimming tests. The scopolamine alone-treated rats exhibited the following: decrease of the spontaneous alternation percentage in Y-maze test, increase of the number of working and reference memory errors in radial arm-maze test, along with decrease of the exploratory activity, the percentage of the time spent and the number of entries in the open arm within elevated plus-maze test and decrease of swimming time and increase of immobility time within forced swimming test. Inhalation of the P. peregrina essential oil significantly improved memory formation and exhibited anxiolytic- and antidepressant-like effects in scopolamine-treated rats. Our results suggest that the P. peregrina essential oil inhalation ameliorates scopolamine-induced memory impairment, anxiety, and depression. Moreover, studies on the P. peregrina essential oil may open a ...Continue Reading

References

Jan 7, 1998·Neuroscience and Biobehavioral Reviews·R J Rodgers, A Dalvi
May 15, 2002·Trends in Pharmacological Sciences·John F CryanIrwin Lucki
Aug 25, 2004·Neurotoxicity Research·Martín CammarotaN Izquierdo
Oct 12, 2004·Behavioural Brain Research·Maria Noêmia M de LimaNadja Schröder
Dec 28, 2004·Journal of Ethnopharmacology·Masoumeh EmamghoreishiMaryam Fath Aazam
Apr 4, 2008·Acta Neurologica Scandinavica·J RissS Collins
May 27, 2008·Chemico-biological Interactions·Sadaharu KotaniHiroo Ogura
Oct 29, 2008·FEBS Letters·Félix Hernández, Jesús Avila
Jan 19, 2010·Journal of Ethnopharmacology·Andressa BlainskiRúbia M W de Oliveira
Apr 20, 2010·Neuroscience and Biobehavioral Reviews·Inge Klinkenberg, Arjan Blokland
Jun 26, 2012·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Gunter P EckertWalter E Muller
Nov 7, 2012·Neuroscience Letters·Yasushi HayashiJunichi Tanaka
Nov 26, 2013·Molecular Nutrition & Food Research·Artur KesslerCarmen Villmann
Jan 24, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Mohamad Khairul Azali SahakDurriyyah Sharifah Hasan Adli
Feb 11, 2014·Neurochemistry International·Chris G Whiteley
Aug 19, 2014·BioMed Research International·Xiao-Ling LiLan Tan
Sep 23, 2014·European Journal of Medicinal Chemistry·Robert OttoChristoph Enzensperger
Dec 3, 2014·Neurobiology of Learning and Memory·Miroljub PopovićMaría Caballero-Bleda
Dec 6, 2014·Journal of Ethnopharmacology·Ibukun F AdebesinOlufunmilayo O Adeyemi
Dec 9, 2014·Alzheimer's Research & Therapy·Pearl BehlDonald T Stuss
Dec 20, 2014·BioMed Research International·Teng MaLan Tan

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Citations

Dec 13, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lucian HritcuMarius Mihasan
Aug 18, 2017·Journal of Cellular and Molecular Medicine·Paula Alexandra PostuLucian Hritcu
Sep 7, 2019·Journal of Complementary & Integrative Medicine·Karima A El-ShamyEman R Youness
Nov 7, 2019·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Sahba JafarianEnoch Kumar Perimal
Jul 22, 2020·Journal of Complementary & Integrative Medicine·Maryam FarahmandReza Negarandeh
Apr 20, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·Rania I NadeemBahia M El-Sayeh
Mar 31, 2018·Current Medicinal Chemistry·Franko BurculOlivera Politeo
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aswir Abd RashedDevi Nair Gunasegavan Rathi
May 23, 2021·Metabolic Brain Disease·Adejoke Elizabeth Memudu, Abosede Esther Adewumi
Feb 21, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Paula Alexandra PostuLucian Hritcu
Apr 22, 2021·CNS & Neurological Disorders Drug Targets·Himanshi Varshney, Yasir Hasan Siddique

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