PMID: 11903412Mar 21, 2002Paper

The effects of intensive glycaemic control on body composition in patients with type 2 diabetes

Diabetes, Obesity & Metabolism
W BaggG D Braatvedt

Abstract

To examine the effects of improved glycaemic control over 20 weeks on the type and distribution of weight change in patients with type 2 diabetes who at baseline have poor glycaemic control. Forty-three patients with type 2 diabetes and HbA1c > 8.9% were randomised to either intensive glycaemic control (IC) n = 21 or usual glycaemic control (UC) n = 22 for 20 weeks. Dual energy X-ray absorptiometry was used to assess the type and distribution of weight change during the study. After 20 weeks HbA1c was significantly lower in patients randomised to IC than UC (HbA1c IC 8.02 +/- 0.25% vs. UC 10.23 +/- 0.23%, p < 0.0001). In the IC group weight increased by 3.2 +/- 0.8 kg after 20 weeks (fat-free mass increased by 1.8 +/- 0.3 kg) compared to 0.02 +/- 0.70 kg in UC (p = 0.003). The gain in total body fat mass comprised trunk fat mass (IC 0.94 +/- 0.5 kg vs. UC 0.04 +/- 0.4 kg, p = 0.18) and peripheral fat mass (total body fat - trunk fat) (IC 0.71 +/- 0.32 kg vs. UC -0.21 +/- 0.28 kg, p = 0.04). Blood pressure and serum lipid concentrations did not change over time in either group. Intensive glycaemic control was associated with weight gain which was distributed in similar proportions between the central and peripheral regions and c...Continue Reading

References

Feb 17, 1992·The Medical Journal of Australia·G Egger
Mar 1, 1992·Diabetic Medicine : a Journal of the British Diabetic Association·T F CundyJ Baker
Sep 1, 1985·Metabolism: Clinical and Experimental·J RodinR A DeFronzo
Feb 1, 1981·American Journal of Epidemiology·W C KnowlerP H Bennett
Jun 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·B H WolffenbuttelA C Nieuwenhuijzen Kruseman
Jan 1, 1996·Diabetic Medicine : a Journal of the British Diabetic Association·A SinhaG Jerums
Oct 1, 1996·Scandinavian Journal of Clinical and Laboratory Investigation·J H Jendle, B E Karlberg
Jun 24, 2000·Annals of the New York Academy of Sciences·G B Forbes

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Citations

Jan 30, 2004·Diabetes, Obesity & Metabolism·H de BoerL Verschoor
Dec 1, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·A SalléP Ritz
Aug 19, 2004·Diabetes Research and Clinical Practice·Simon Heller
Aug 18, 2004·Journal of the American College of Cardiology·Gillian A WhalleyJames C Baldi
Dec 2, 2017·The International Journal of Pharmacy Practice·Soik Fun LeeRita Pauline James
Jul 30, 2015·The Cochrane Database of Systematic Reviews·Bianca HemmingsenJørn Wetterslev
Aug 13, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A Fritsche, H Häring
Jul 22, 2010·British Journal of Nursing : BJN·Catherine Whitmore
Nov 7, 2019·BMJ : British Medical Journal·René Rodriguez-GutierrezRozalina G McCoy

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