The effects of interaction between familial and reproductive factors on breast cancer risk: a combined analysis of seven case-control studies

British Journal of Cancer
Nadine AndrieuN E Day

Abstract

In this paper, a combined analysis was performed to study the interaction between familial risk and reproductive life factors. In particular, the interaction between familial risk and breast cell mitotic activity (BCMA), as assessed by duration of ovarian activity, was investigated because of the potential importance of mitotic activity on genetically susceptible cells. The present analysis included 3152 cases and 4404 controls in seven case-control studies from four countries. The interaction effect was estimated in each study separately, then combined using two different methods: a multivariate weighted average and a Bayesian random-effects model. The main effects of reproductive life factors on the risk of breast cancer were in agreement with the previous findings. In particular, an increased duration of BCMA before the first childbirth and over life was found to increase the risk of breast cancer (P < 0.001). Slightly increasing but non-significant, familial risks were observed with increasing number of children (P = 0.17), increasing age at first childbirth (P > 0.2) and increasing duration of BCMA (P > 0.2). There was no modification in familial risk with age at menarche and no clear pattern with menopause characteristics...Continue Reading

Citations

Aug 3, 2013·European Journal of Nutrition·Natalia TumasMaría del Pilar Díaz
May 7, 2002·International Journal of Cancer. Journal International Du Cancer·Béatrice Geoffroy-PerezNadine Andrieu
Dec 11, 2013·International Journal of Cancer. Journal International Du Cancer·Zhezhou HuangXiao-Ou Shu
Oct 21, 2016·Clinical Obstetrics and Gynecology·Kristin Rojas, Ashley Stuckey
Oct 13, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Christopher I LiEmily White

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