The effects of intraarticularly injected sodium hyaluronate on levels of intact aggrecan and nitric oxide in the joint fluid of patients with knee osteoarthritis

Osteoarthritis and Cartilage
Kohei KobayashiHideshige Moriya

Abstract

Intraarticular injections of sodium hyaluronate (Na-HA) appear effective in reducing subjective symptoms of osteoarthritis (OA) and may also have protective effects on the cartilage matrix. The present study analyzed the suppressive effects of Na-HA on the release and degradation of aggrecan and on levels of nitric oxide (NO) in the joint fluid of patients with knee OA. Sixteen OA patients with knee joint effusion were treated by 5 weekly intraarticular injections of Na-HA. Prior to each Na-HA injection, joint fluid was collected to determine the levels of chondroitin 4-sulfate (C4S) and chondroitin 6-sulfate (C6S), intact aggrecan and NO. One week after the final injection, the joint fluid levels of C4S, C6S, and NO were significantly decreased. In contrast, the joint fluid level of intact aggrecan was stable during the series of Na-HA injections. A trend was seen for a positive correlation (P < 0.1) between the clinical score and C4S or C6S joint fluid levels, and for a negative correlation between the joint fluid levels of intact aggrecan and C4S or C6S. No significant correlations were observed between joint fluid levels of NO, the clinical score, and levels of C4S, C6S, and intact aggrecan. The results of this study sugges...Continue Reading

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Citations

Sep 30, 2008·Chinese Journal of Traumatology = Zhonghua Chuang Shang Za Zhi·Bo QiuHao Peng
Mar 4, 2005·Arthritis Research & Therapy·Xiaotian ChangKazuhiko Yamamoto
Sep 6, 2008·Journal of the Chinese Medical Association : JCMA·Chen-Liang ChouHsiao-Yi Ling
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Sep 22, 2017·Therapeutic Advances in Musculoskeletal Disease·Mohit BhandariJean-Pierre Pelletier
Dec 9, 2017·Cartilage·Roy D AltmanJun Takeuchi
May 18, 2020·Scientific Reports·Ferenc Horkay, Peter J Basser

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