The effects of intracoeliac injections of alpha-adrenergic agonists and veratridine on reticuloruminal motility and the evocation of rumination in sheep

Zentralblatt für Veterinärmedizin. Reihe A
D P Campion, B F Leek

Abstract

The ability of alpha-2 adrenoreceptor agonists and veratridine to evoke rumination and to modify reticular motility in adult Suffolk-cross sheep when injected by close-arterial injection into the forestomach was investigated. The specific alpha-2 adrenoreceptor agonists, xylazine and medetomidine, evoked rumination and increased reticular motility. The Na+ channel activator veratridine also evoked rumination and dramatically increased reticular motility. In contrast, injection of the alpha-1 adrenoreceptor agonist, phenylephrine, was ineffectual in evoking rumination and resulted in reduced reticular motility. It is concluded that the evocation of rumination by alpha-2 adrenergic agonists and veratridine is probably due to the activation of sensory nervous receptors (epithelial receptors) located in the reticulorumen.

References

Jan 1, 1973·Physiological Reviews·A S Paintal
Dec 1, 1983·Journal of Veterinary Pharmacology and Therapeutics·Y Ruckebusch
Jan 1, 1980·Annual Review of Pharmacology and Toxicology·W A Catterall

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Citations

Feb 16, 2006·Veterinary Anaesthesia and Analgesia·Sabine B R Kästner
Oct 12, 2002·American Journal of Veterinary Research·Martha J HardingRuben O Donis

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