PMID: 9442788Jan 27, 1998Paper

The effects of intraocular lidocaine on the corneal endothelium

Ophthalmology
T KimH F Edelhauser

Abstract

The study aimed to evaluate the direct effect of intraocular lidocaine hydrochloride (HCl) 1% on corneal endothelial cell function, ultrastructure, and viability using an in vitro perfusion specular microscope system. Paired rabbit and human corneas were isolated and mounted in an in vitro specular microscope for endothelial perfusion evaluation. Corneas were perfused with a control solution (BSS Plus for humans, glutathione bicarbonate Ringer's [GBR] for rabbits) for a 1-hour stabilization period. After the stabilization period, one cornea of each matched pair was perfused with preservative-free lidocaine HCl 1% for 15 minutes followed by control solution for an additional 2 to 3 hours. The control cornea continued to receive either GBR or BSS Plus. Corneal thickness measurements were taken every 15 minutes throughout the perfusion period. Corneal swelling and deswelling rates were calculated by linear regression analysis. At the end of the experiment, corneas were fixed for scanning and transmission electron microscopy. In another group of corneas, the endothelial viability was assayed after direct perfusion with lidocaine HCl 1%. Lidocaine HCl 1% caused endothelial cell edema, which reversed on removal of lidocaine from perf...Continue Reading

References

May 1, 1988·Ophthalmology·C M MorganR Rudich
Dec 1, 1987·Anesthesia and Analgesia·J M NicollK R Edge
Jan 1, 1995·Journal of Cataract and Refractive Surgery·C J Anderson
Jun 1, 1995·Archives of Ophthalmology·T L MeansH F Edelhauser
Jul 1, 1994·Journal of Cataract and Refractive Surgery·H Fukasaku, J A Marron
Jun 1, 1996·Ophthalmology·H CapóR M Siatkowski

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Citations

Jan 8, 2010·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Marie-Thérèse BawolakFrançois Marceau
Sep 25, 2002·Transplantation Proceedings·T BredehornG I W Duncker
Jun 1, 2000·Journal of Cataract and Refractive Surgery·J H Tan, R L Burton
Sep 28, 2004·Cornea·H Keith RiddleFrancis W Price
Nov 5, 2004·American Journal of Veterinary Research·Paul A GerdingDavid J Schaeffer
May 20, 1999·Journal of Cataract and Refractive Surgery·C WirbelauerH Laqua
May 20, 1999·Journal of Cataract and Refractive Surgery·I S BarequetT P O'Brien
Apr 17, 2002·Journal of Cataract and Refractive Surgery·Gabriele Fuchsjäger-MayrlKlaus Turnheim
May 31, 2002·Journal of Cataract and Refractive Surgery·Glenn P HolleyHenry F Edelhauser
Mar 29, 2003·Journal of Cataract and Refractive Surgery·Tamer A MackyRupal H Trivedi
Jan 8, 2004·Journal of Cataract and Refractive Surgery·Robert J CionniRobert H Osher
Oct 6, 2000·Journal of Cataract and Refractive Surgery·P EggelingP W Rieck
Nov 21, 2000·Journal of Cataract and Refractive Surgery·P LanzettaU Menchini
Dec 14, 2011·Survey of Ophthalmology·David J AppleAndreas F Borkenstein
Dec 24, 2010·Journal français d'ophtalmologie·P-L Cornut, C Chiquet
Sep 25, 2008·Journal of Cataract and Refractive Surgery·Giorgio LofocoAndrea Cacciamani
Feb 16, 2007·The British Journal of Dermatology·G MorissetteF Marceau
Mar 28, 2006·Journal of Cataract and Refractive Surgery·Nick MamalisLiliana Werner
Sep 29, 2006·Korean Journal of Ophthalmology : KJO·Jun-Heon KimJaeryung Oh
Jun 5, 2004·Journal of Cataract and Refractive Surgery·Shiow-Wen LiouI-Jong Wang
Jul 20, 2007·The Cochrane Database of Systematic Reviews·D G Ezra, B D Allan
Mar 21, 2000·Current Opinion in Ophthalmology·J Naor, A R Slomovic
Feb 13, 2003·Clinical & Experimental Ophthalmology·Huban AtillaYüksel Saran
Jul 31, 2003·Current Opinion in Ophthalmology·C H Parikh, H F Edelhauser
Aug 18, 2018·Oxidative Medicine and Cellular Longevity·Guojian Jiang, Tingjun Fan
Oct 24, 2020·International Ophthalmology Clinics·Tahira M Scholle

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