The effects of intrathecal gabapentin on spinal morphine tolerance in the rat tail-flick and paw pressure tests.

Anesthesia and Analgesia
C HansenM Hong

Abstract

Analgesic tolerance to opioids has been described in both experimental and clinical conditions and may limit the clinical utility of these drugs. We have previously shown that systemic gabapentin (GBP), a non-opioid drug, prevents and reverses tolerance to systemic morphine in the rat. In this study, we investigated the effect of intrathecal GBP on spinal morphine tolerance. Studied rats were given 7 days of intrathecal injections with saline (10 microL), GBP (300 microg), morphine (15 microg), or a GBP-morphine combination, and analgesic testing using tail-flick and paw-pressure tests was conducted before and 30 min after the drug injection. On Day 8, an antinociceptive dose-response curve was constructed and the 50% effective dose (ED(50)) values for morphine (given alone) were calculated for each study group. Coinjection of GBP with morphine blocked the development of tolerance, as shown by the preservation of morphine analgesia over 7 days as well as by a concomitant decrease in ED(50) values on Day 8, as compared with the morphine-alone group. Although additive analgesia over Days 1-7 cannot be ruled out, ED(50) reductions in the GBP-morphine combination group indeed suggest some suppression of tolerance. These data suppor...Continue Reading

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Citations

Jun 2, 2006·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Ian Gilron
Sep 18, 2007·Journal of Molecular Neuroscience : MN·Jamil Ahsan Kazi, Chen Fun Gee
Aug 25, 2010·Journal of Molecular Neuroscience : MN·Jamil Ahsan Kazi, Mohamed Ibrahim Abu-Hassan
Sep 8, 2011·Journal of Anaesthesiology, Clinical Pharmacology·Dalim Kumar BaidyaMahesh Kumar Arora
Mar 17, 2007·Neuroscience Letters·Joseph OommenRobert S Fisher
Jul 26, 2005·Peptides·Richard J Bodnar, Gad E Klein
May 12, 2012·European Journal of Pharmacology·Harshini Neelakantan, Ellen A Walker
Feb 14, 2006·Journal of Pharmacological Sciences·Jen-Kun Cheng, Lih-Chu Chiou
Feb 23, 2008·Anesthesiology·Alain C Van ElstraeteDan Benhamou
Dec 1, 2017·Current Neuropharmacology·Dai-Qiang LiuFeng Gao
Apr 24, 2012·Anesthesia and Analgesia·Delia AguadoIgnacio A Gómez de Segura
Nov 20, 2013·Neuroreport·Yu-Hua BaoDongping Du
Nov 29, 2007·Anesthesia and Analgesia·Noor M Gajraj
Jan 18, 2006·British Journal of Anaesthesia·D J Rowbotham

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