The effects of intravaginal clindamycin and metronidazole therapy on vaginal lactobacilli in patients with bacterial vaginosis

American Journal of Obstetrics and Gynecology
Paul NyirjesyJames L Joffrion

Abstract

The purpose of this study was to determine the effects of 3 intravaginal antibacterial treatments on vaginal lactobacilli in patients with bacterial vaginosis (BV). Retrospective analyses were performed on Lactobacillus scores from 3 similar studies evaluating 2 2% clindamycin vaginal creams and 0.75% metronidazole gel at baseline and at 21 to 30 days in 408 patients with BV. Scores were compared using a 1-way global F test and McNemar's test. All groups had similar mean Lactobacillus scores at baseline (P = 0.37) and at 21 to 30 days (P = .71). The 3 groups were also comparable at both visits with respect to the distributions of scores within each group. In all groups, there was significant improvement in the percentages of patients with no lactobacilli present at 21 to 30 days compared with baseline (P < .0001 for all comparisons). Clindamycin and metronidazole promoted similar levels of restoration of vaginal lactobacilli at 21 to 30 days.

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Citations

Jan 5, 2010·Journal of Women's Health·Judy Y ChenRichard H Beigi
Oct 1, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·L Petricevic, A Witt
Sep 16, 2014·Best Practice & Research. Clinical Obstetrics & Gynaecology·Anna M Powell, Paul Nyirjesy
Jan 1, 2013·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Gilbert G G DondersUNKNOWN VARIANT 1 Study Group
Apr 1, 2010·BMC Infectious Diseases·Hans VerstraelenMarleen Temmerman
Jan 1, 2008·Interdisciplinary Perspectives on Infectious Diseases·Sujatha Srinivasan, David N Fredricks

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Bacterial vaginosis can increase the risk of sexually transmitted infections and in rare cases lead to pelvic inflammatory diseases. Discover the latest research on Bacterial Vaginosis here.