The effects of intravenous anaesthetics on the cardiovascular system of the rabbit

British Journal of Pharmacology
J C McGrath, J E MacKenzie


1 A pithed rabbit preparation is described that allows selective stimulation of the vertebral outflows. 2 The responses to stimulation of sympathetic vasopressor fibres were blocked by hexamethonium and phentolamine but potentiated by cocaine, whereas the responses to stimulation of cardioaccelerator fibres were blocked by propranolol. 3 Ketamine, althesin and pentobarbitone enhanced the effects of noradrenaline and attenuated the effects of sympathetic nerve stimulation. Thiopentone enhanced the effects of both noradrenaline and sympathetic nerve stimulation. 4 In pithed rabbits a transient, dose-related cardiovascular depression was produced by each agent irrespective of whether vasomotor tone was present whereas in decerebrate rabbits the corresponding cardiovascular depression was longer lasting. 5 It is concluded that the cardiovascular depression produced by intravenous anaesthetics in intact rabbits is due to a combination of central and peripheral effects.


May 1, 1976·Canadian Anaesthetists' Society Journal·J E MacKenzieR A Millar
Oct 1, 1976·British Journal of Pharmacology·A S Clanachan, J C McGrath
Aug 1, 1975·The Journal of Pharmacology and Experimental Therapeutics·D A Schwartz, L D Horwitz
Oct 1, 1975·Anesthesiology·B T Altura, B M Altura
May 1, 1967·British Journal of Pharmacology and Chemotherapy·J S Gillespie, T C Muir
May 1, 1973·The Journal of Physiology·J S Gillespie, J C McGrath
Aug 1, 1973·European Journal of Pharmacology·O A Nedergaard
Oct 1, 1971·British Journal of Anaesthesia·R S ClarkeJ G Bovill
Sep 1, 1968·Anesthesiology·E G Dowdy, K Kaya
May 1, 1967·British Journal of Pharmacology and Chemotherapy·J S Gillespie, T C Muir
Jan 1, 1954·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·G FEGLER
Jun 1, 1961·British Journal of Pharmacology and Chemotherapy·E MUSCHOLL
May 1, 1965·Clinical Pharmacology and Therapeutics·E F DOMINOG CORSSEN
Jun 1, 1955·The Quarterly Review of Biology·G B WEST
Apr 1, 1960·Physiological Reviews·H L PRICE

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Jan 1, 1978·British Journal of Pharmacology·R L Hughes, J E MacKenzie
Oct 1, 1980·British Journal of Pharmacology·B M AlturaA Carella
May 1, 1988·British Journal of Pharmacology·J M Bulloch, J C McGrath
Jun 1, 1994·The Australian & New Zealand Journal of Obstetrics & Gynaecology·A A Calder
Sep 1, 1979·Clinical and Experimental Pharmacology & Physiology·J M Elliott
Apr 7, 2004·Journal of Biomedical Science·Tsai-Yueh LuoMing-Jai Su

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