PMID: 10210290Apr 21, 1999

The effects of ischemic preconditioning on resting coronary flow and reactive hyperemia: involvement of A1 adenosine receptors

Life Sciences
P PagliaroD Gattullo


During the myocardial protection induced by ischemic preconditioning a reduction in myocardial metabolism occurs due to activation of the A1 adenosine receptors. This study investigates whether preconditioning changes both resting coronary flow and the magnitude of coronary reactive hyperemia and whether A1 adenosine receptors are involved in the observed changes. Experiments were performed in 14 goats (30-50 kg body weight). After the animals were anesthetized with ketamine, an electromagnetic flow-probe was used to record blood flow in the left circumflex coronary artery. Distal to the probe, an occluder was placed to produce ischemic preconditioning and reactive hyperemia. Preconditioning was obtained with two periods of 2.5 min of coronary occlusion separated from each other by 5 min of reperfusion. Coronary reactive hyperemia was obtained with 15 s of occlusion of the artery before and after preconditioning. In a group of goats before preconditioning 0.2 mg kg(-1) of 8-cyclopentyl-dipropylxanthine (CPX), an A1 adenosine receptor blocker, were given intravenously. In all animals ischemic preconditioning did not alter resting coronary flow, but, in the absence of A1 adenosine receptor blockade, reduced the reactive hyperemic...Continue Reading


Sep 1, 1973·Circulation Research·E Eikens, D E Wilcken
Dec 1, 1980·Circulation Research·R M Berne
Apr 1, 1983·Cardiovascular Research·H F DowneyF A Bashour
Jun 17, 1994·Annals of the New York Academy of Sciences·K A ReimerR B Jennings
Apr 1, 1993·Cardiovascular Research·C S Lawson, J M Downey
Jan 1, 1996·Life Sciences·G LosanoP Pagliaro

Related Concepts

PD 116948
Adenosine Triphosphate, Chromium Ammonium Salt
Coronary Circulation
Reactive Hyperemia
Receptors, Purinergic P1
Ischemic Preconditioning

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