The effects of ivermectin on transmission of Onchocerca volvulus

Science
E W CuppB M Greene

Abstract

Ivermectin, given to onchocerciasis patients as a single oral dose of 200 micrograms per kilogram of body weight, substantially reduced the uptake of Onchocerca volvulus microfilariae by Simulium yahense, an efficient black fly vector of the parasite in the tropical rain forests of West Africa. Three months after treatment, patients given ivermectin infected flies at a significantly lower rate than those who had received diethylcarbamazine or placebo, thereby reducing the number of developing larvae in the vector population. This diminished rate of infectiousness was also evident 6 months after treatment. These results strongly suggest that ivermectin could be effective in interrupting transmission of Onchocerca volvulus for epidemiologically important periods of time.

References

Jul 1, 1978·The British Journal of Ophthalmology·J Anderson, H Fuglsang
Jul 18, 1985·The New England Journal of Medicine·B M GreeneL P Goldschmidt
Jan 1, 1972·British Medical Bulletin·B O Duke
Aug 26, 1983·Science·W C CampbellT A Jacob
May 1, 1984·The American Journal of Tropical Medicine and Hygiene·V K Barbiero, M Trpis
Oct 10, 1981·British Medical Journal·B O Duke

❮ Previous
Next ❯

Citations

Dec 1, 1987·International Ophthalmology·H R Taylor
May 1, 1990·International Ophthalmology·H R Taylor
Jul 15, 1989·Biochemical Pharmacology·J M Schaeffer, H W Haines
Jan 1, 1994·Transactions of the Royal Society of Tropical Medicine and Hygiene·S TownsonV P Titanji
Sep 1, 1995·Transactions of the Royal Society of Tropical Medicine and Hygiene·D C ChavasseJ B Davies
Jan 1, 1991·Parasitology Today·E A Vande Waa
Jan 1, 1991·Parasitology Today·L D Edungbola
Feb 1, 1992·Parasitology Today·S Dissanayake, W F Piessens
Aug 1, 1989·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G R LankasR T Robertson
Jan 5, 2002·Trends in Parasitology·F O RichardsA Sékétéli
Oct 1, 1993·Medical and Veterinary Entomology·J M Prud'homD Quillevere
Jul 7, 2011·Journal of Global Infectious Diseases·Kevin L WinthropVan C Lansingh
Feb 1, 2011·North American Journal of Medical Sciences·Okwuoma AbanobiKenneth Opara
Jan 18, 2007·Annals of Tropical Medicine and Parasitology·B Thylefors, M Alleman
Jul 25, 2000·Lancet·F RichardsE Cupp
Jul 15, 1990·American Journal of Ophthalmology·A RothovaR F Barbe
Jan 1, 1992·Documenta Ophthalmologica. Advances in Ophthalmology·F L NjooA van der Lelij
Jul 23, 2014·ACS Chemical Biology·Kristina N-M DaefflerDennis A Dougherty
Oct 2, 2007·Lancet·Ed CuppMark Eberhard
Nov 1, 1989·Australian and New Zealand Journal of Ophthalmology·H R Taylor
Sep 1, 1988·Journal of Veterinary Pharmacology and Therapeutics·P L ToutainM Alvinerie
Oct 26, 2011·Parasites & Vectors·Ken GustavsenMauricio Sauerbrey
Apr 1, 2009·PLoS Neglected Tropical Diseases·Rodrigo J GonzalezKim A Lindblade
Oct 20, 2010·PLoS Neglected Tropical Diseases·Judith R DeneryKim D Janda
Sep 28, 2006·PLoS Medicine·María-Gloria BasáñezMichel Boussinesq
Jun 10, 2016·Invertebrate Neuroscience : in·Adrian J WolstenholmeBarbara J Reaves
Apr 19, 1990·The New England Journal of Medicine·P F Weller, L X Liu
Mar 16, 2017·The Journal of Antibiotics·Naftale KatzSatoshi Ōmura
Nov 1, 1987·International Journal of Dermatology·M J MasoW C Lambert
Jan 25, 2020·Annual Review of Pathology·Tory P JohnsonAvindra Nath
Apr 14, 2004·Tropical Medicine & International Health : TM & IH·James M Tielsch, Arlyne Beeche
Apr 25, 2018·Parasites & Vectors·Ángel GuevaraRonald H Guderian
Apr 1, 1990·DICP : the Annals of Pharmacotherapy·E I EtteJ I Achumba
Jul 16, 2019·Infectious Diseases of Poverty·Ed CuppThomas R Unnasch
Feb 1, 1995·Annals of Tropical Medicine and Parasitology·J C Anosike, C O Onwuliri

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.