The effects of Jerusalem artichoke and fermented soybean powder mixture supplementation on blood glucose and oxidative stress in subjects with prediabetes or newly diagnosed type 2 diabetes

Nutrition & Diabetes
Hyeon Yeong AhnJong Ho Lee

Abstract

The objective of this study was to evaluate the effect of supplementation with a Jerusalem artichoke and fermented soybean powder mixture on blood glucose and oxidative stress levels. This randomized, double-blinded, placebo-controlled study was conducted on 60 subjects with impaired fasting glucose (IFG), impaired glucose tolerance (IGT), or newly diagnosed type 2 diabetes. The subjects were randomly assigned to either a group that ingested 40 g of a Jerusalem artichoke and fermented soybean powder mixture (19.45 g each) daily or a group that received a placebo for 12 weeks. Paired t-test and independent t-test were performed for comparisons within groups and between groups, respectively. Supplementation with the Jerusalem artichoke and fermented soybean powder mixture reduced the levels of fasting glucose (p < 0.001) and FFAs (p = 0.034), glucose at 60 min (p = 0.004), glucose (p = 0.006) areas under the response curve (AUC), homeostasis model assessment-insulin resistance (p = 0.018), and the urinary 8-epi-prostaglandin F2α (8-epi-PGF2α) level (p = 0.028). The changes (Δ) in urinary 8-epi-PGF2α, glucose at 60 min, 120 min, and AUC, FFAs at 0 min and AUC were significantly different between the two groups. In addition, Δ gluc...Continue Reading

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Citations

Sep 8, 2020·Expert Opinion on Pharmacotherapy·Marc Rendell
Jan 20, 2021·Complementary Therapies in Medicine·Mozhgan MoradiMohammad Hosein Farzaei
Apr 23, 2021·Expert Review of Clinical Pharmacology·Diorge Jonatas MarmittClaudete Rempel
Aug 13, 2021·International Journal of Clinical Practice·Sajjad MoradiMohammad Hossein Rouhani
Sep 22, 2020·Complementary Therapies in Medicine·Cyrus JaliliMaryam Miraghajani

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Methods Mentioned

BETA
ELISA
Assay
MDA

Clinical Trials Mentioned

NCT02506582

Software Mentioned

SAS
SPSS

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