The effects of keratinocyte growth factor on healing of tympanic membrane perforations

The Laryngoscope
M A ClymerJ M Davidson

Abstract

Tympanic membrane (TM) perforations heal by reepithelialization and fibrous layer proliferation. The rat TM model may be used to study growth factors that promote epithelialization and fibroblast proliferation, such as epidermal growth factor (EGF) and fibroblast growth factor (FGF). The authors previously evaluated the effects of FGF on tympanic membrane perforations and showed an enhanced rate of wound healing with preservation of normal structure and function. The same model was used to test keratinocyte growth factor (KGF, also called FGF-7). This growth factor has been shown to stimulate the migration and proliferation of keratinocytes. This is the first study investigating KGF in the tympanic membrane perforation model. Our results show that in contrast to FGF and EGF, KGF does not enhance the rate of wound healing, but rather results in a more organized wound repair process.

References

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Citations

Oct 4, 2012·Tissue Engineering. Part B, Reviews·Bing Mei TehMarcus D Atlas
May 13, 2008·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Holger KaftanMichael Herzog
Feb 13, 2007·Immunological Reviews·Julie Jameson, Wendy L Havran
Oct 29, 2011·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·Z-C LouJ Yang
Sep 9, 2010·The Laryngoscope·Peter Luke Santa MariaReza Ghassemifar
Dec 7, 2013·The Laryngoscope·Issam SalibaSylvain Chemtob
Jan 30, 2003·The British Journal of Surgery·S P BennettS L Schor
Mar 5, 2013·Otolaryngologia polska. The Polish otolaryngology·Katarzyna Guzińska-UstymowiczElżbieta Hassmann-Poznańska
Jul 27, 1999·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·P M SolerM C Robson
Nov 12, 2015·Audiology Research·Maria A Villar-Fernandez, Jose A Lopez-Escamez

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