The effects of ketorolac and morphine on articular cartilage and synovium in the rabbit knee joint

Canadian Journal of Physiology and Pharmacology
Nazim DoganMehmet Kizilkaya

Abstract

Analgesics are commonly injected intra-articularly for analgesia after arthroscopic surgery, especially of knee joints. The aim of this study was to research the effects of ketorolac and morphine on articular cartilage and synovial membrane. This study used rabbit right and left hind knee joints. The treatments, saline, morphine, or ketorolac, were administered intra-articularly 24 h after injection, and 5 joints from animals in each drug group were chosen randomly to form Group I and subgroups of Group I. The same procedures were applied after 48 h and 10 days of injection to form Groups II and III, respectively, and subgroups of these groups. Knee joints were excised and a blinded observer evaluated the histopathology according to inflammation of the articular cartilage, inflammatory cell infiltration, hypertrophy, and hyperplasia of the synovial membrane. No histopathological changes were found in the control groups. In the ketorolac and morphine groups, there were varying degrees of synovial membrane inflammatory cell infiltration and minimal, mild, or moderate synovial membrane cell hyperplasia or hypertrophy. Except for the ketorolac group at 24 h, both ketorolac and morphine groups showed more histopathological changes t...Continue Reading

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Citations

Jul 27, 2011·Rheumatology International·Susanne SchroederThomas Woehrmann
Sep 10, 2008·Hand : Official Journal of the American Association for Hand Surgery·Paul S ShapiroA Seth Greenwald
Jul 3, 2013·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Knut BeitzelAugustus D Mazzocca
Jul 2, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Corinne N RigginAndrew F Kuntz
Jul 26, 2005·Peptides·Richard J Bodnar, Gad E Klein
Jun 28, 2005·Biochemical and Biophysical Research Communications·Nenad AndjelkovOddmund Johansen
Apr 24, 2009·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Weifeng ShenHonghai Wu
Apr 16, 2019·Acta orthopaedica et traumatologica turcica·Emine Çepni KütahyaOguzhan Arun

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