PMID: 9556817Apr 29, 1998Paper

The effects of L-arginine and iloprost on the viability of random skin flaps in rats

Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery
A R ErçöçenE Yormuk

Abstract

The effects of an intravenous infusion of L-arginine as a physiological precursor of endothelium-derived relaxing factor/nitric oxide (EDRF/NO), iloprost (a stable prostacyclin (PGI2) analogue), and L-arginine combined with iloprost on skin viability were studied in 9 x 3 cm random pattern skin flaps in rats. Intravenous infusion of all drugs was started at the beginning of the operation and continued for 60 minutes. At the end of infusion period the depth of fluorescein dye penetration in the skin flap was assessed visually from photographic records, and the flap survival area was measured by the grid method at the seventh postoperative day. There was a significant reduction in distal necrosis of random skin flaps after intravenous infusion of L-arginine, iloprost, and L-arginine combined with iloprost (p < 0.01). Possible mechanisms that may be responsible for impairment of endothelium-dependent vasodilation and vasospasm in the microvasculature of random skin flap and their prevention with L-arginine and iloprost include restoration of the depleted stores of NO which in turn causes vasodilatation and has an antithrombotic effect.

References

Sep 1, 1992·Canadian Journal of Physiology and Pharmacology·M L KreidsteinN Xu
Apr 1, 1991·British Journal of Pharmacology·H MoritokiS Takeuchi
Mar 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S PalaogluR K Turker
Feb 1, 1991·The Journal of Surgical Research·K R KnightK Sakai
Apr 1, 1991·Plastic and Reconstructive Surgery·M L KreidsteinR J Knowlton
Dec 1, 1990·Circulation Research·X J GirerdM A Creager
Jan 1, 1988·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R K TürkerZ S Ercan
Sep 15, 1989·Biochemical and Biophysical Research Communications·K AisakaR Levi
Jan 17, 1985·The New England Journal of Medicine·J M McCord
Oct 1, 1988·Journal of Reconstructive Microsurgery·K G Proctor, S Shatkin
Aug 1, 1986·Annals of Plastic Surgery·L S ZacharyR C Murphy
Jun 30, 1988·Biochemical and Biophysical Research Communications·R M PalmerS Moncada
Jul 1, 1973·British Journal of Plastic Surgery·I A McGregor, G Morgan
Nov 1, 1974·Plastic and Reconstructive Surgery·J F Reinisch
Jun 1, 1982·Plastic and Reconstructive Surgery·J D Welch
May 1, 1982·Plastic and Reconstructive Surgery·H MisholyC L Puckett
Nov 1, 1982·Plastic and Reconstructive Surgery·C L Kerrigan, R K Daniel
May 1, 1994·Annals of Plastic Surgery·D M SenderoffH Weinberg
Jan 1, 1993·Journal of Cardiovascular Pharmacology·C Y PangN Xu
Feb 1, 1994·Plastic and Reconstructive Surgery·V E HjortdalS Solymoss

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Citations

Jan 15, 2008·Cellular and Molecular Life Sciences : CMLS·J S IsenbergD D Roberts
Apr 23, 2003·Burns : Journal of the International Society for Burn Injuries·Emrah ArslanGürbüz Polat
Jun 28, 2003·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Ali Riza ErçöçenMotohiro Nozaki
Apr 13, 2007·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·C ContaldoD Erni
Sep 27, 2005·Journal of the American College of Surgeons·Shelby G ToppWilliam C Lineaweaver
Oct 1, 2008·Current Therapeutic Research, Clinical and Experimental·Kaan GiderogluGuler Bugdayci
Sep 30, 2010·Acta Cirúrgica Brasileira·Gustavo Roberto de GodoyLydia Masako Ferreira
Apr 5, 2002·Plastic and Reconstructive Surgery·Kayvan T Khiabani, Carolyn L Kerrigan
Jun 24, 2004·Annals of Plastic Surgery·Ewa Komorowska-TimekHarry J Buncke
Oct 27, 2004·Annals of Plastic Surgery·Eksal KargiBulent Erdogan
Jul 27, 2005·Microsurgery·Jeff S IsenbergDavid D Roberts
Jun 28, 2019·Plastic and Reconstructive Surgery·Fatma Betul TuncerOzhan Celebiler
May 28, 2005·Anesthesia and Analgesia·Yves HarderDominique Erni
Apr 26, 2020·Journal of Plastic Surgery and Hand Surgery·Alper Burak Uslu
Dec 19, 2019·Annals of Plastic Surgery·Emre GazyakanHolger Engel
Apr 9, 2001·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·H ErgünF C Tulunay
Apr 26, 2005·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·Mithat AkanTayfun Aköz
Sep 8, 2020·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Emre GazyakanHolger Engel

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