The effects of labetalol (AH 5158) on adrenergic transmission in the cat spleen

British Journal of Pharmacology
A G Blakeley, R J Summers

Abstract

1. The competitive alpha- and beta-adrenoceptor blocking agent labetalol, in concentrations up to 10(-4) M, produced dose-dependent increases in transmitter overflow from the isolated blood perfused spleen of the cat following nerve stimulation at 10 and 30 Hz. 2. At concentrations above 10(-4) M labetol produced a pronounced decrease in transmitter overflow. 3. Labetalol (1.5 X 10(-4) M) increased the recovery of 3H label in the venous blood following the close-arterial infusion of [3H]-(-)-noradrenaline indicating that the drug inhibits uptake of the amine. 4. Both labetalol (3.8 X 10(-5) M) and piperoxan (7.4 X 10(-6) M) produced parallel shifts to the right of the dose-response curves to noradrenaline and oxymetazoline in isolated strips of cat splenic capsule. In this preparation both drugs acted as competitive postsynaptic alpha-adrenoceptor blocking agents. 5. Labetalol (3.3 X 10(-5) M) increased the transmitter overflow following stimulation of the splenic nerves with 200 impulses at 10 Hz. The overflow could be further increased by subsequent addition of piperoxan (7.2 X 10(-6 M). Piperoxan (5.7 X 10(-6) M) alone produced a marked increase in transmitter overflow which could be further increased by subsequent addition ...Continue Reading

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Citations

Nov 1, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·S A Doggrell, D M Paton
Jan 1, 1983·Pharmacology & Therapeutics·A J Scriven, P J Lewis
Jan 1, 1978·General Pharmacology·A G Blakeley, R J Summers
Jan 1, 1997·Pharmacology & Therapeutics·S M KhedunB Maharaj
Jun 1, 1978·British Journal of Clinical Pharmacology·D A RichardsB N Prichard
Apr 1, 1979·British Journal of Clinical Pharmacology·D A RichardsR Hernández
Jan 1, 1982·Clinical and Experimental Pharmacology & Physiology·G A McPherson, R J Summers
Apr 1, 1979·British Journal of Pharmacology·R J Summers, J Tillman
Jan 1, 1983·Clinical and Experimental Hypertension. Part A, Theory and Practice·M L Cohen, L M Hynes
Jul 1, 1978·The Journal of Pharmacy and Pharmacology·S A Doggrell, D M Paton
Aug 1, 1984·The Journal of Pharmacy and Pharmacology·T TakenakaN Inukai
Jan 1, 1982·Acta Medica Scandinavica. Supplementum·K E Andersson
Apr 1, 1979·British Journal of Clinical Pharmacology·L Kaufman
Apr 1, 1979·British Journal of Clinical Pharmacology·B N Prichard, D A Richards
Jan 1, 1979·Pharmacological Research Communications·H Kapur, D R Mottram

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