The effects of large doses of methylprednisolone on neurologic recovery and survival in the Mongolian gerbil following three hours of unilateral carotid occlusion

Central Nervous System Trauma : Journal of the American Paralysis Association
J M Braughler, M J Lainer

Abstract

Using a scoring system designed to assess the severity of neurologic deficit in gerbils during and after temporary unilateral carotid occlusion, the effects of large doses of methylprednisolone sodium succinate (MPSS: Solu-Medrol sterile powder) on experimental stroke have been examined. By scoring gerbils hourly for torso curvature, circling, inability to walk, ptosis, barrel rolling, opisthotonus, generalized seizures, and loss of righting reflex, their level of neurologic deficit can be easily, quantitatively, and reproducibly evaluated. Approximately 37% of gerbils subjects to a 3-hour unilateral carotid occlusion attained average scores of 4.0-4.5 during the first hour. There was a slight, though not significant, worsening (increase) of scores over the 3-hour occlusion period that was not altered by pretreatment of gerbils with 60 mg/kg of MPSS 10 minutes before occlusion. Following removal of occlusion at 3 hours, gerbils recovered only minimally during the ensuing 4-hour period, with deficit scores remaining around 3.2 +/- 0.3. Pretreatment of gerbils with 60 mg/kg of MPSS, however, resulted in a striking improvement in their deficit scores to 1.6 +/- 0.2 (p less than 0.05) by 2 hours after occlusion removal. Treatment o...Continue Reading

References

Feb 14, 1979·Biochemical and Biophysical Research Communications·R J Gaudet, L Levine
Jan 1, 1975·Journal of Neural Transmission·M LavyneR Wurtman
Nov 1, 1982·Pharmacology, Biochemistry, and Behavior·A J KastinR D Olson
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B K Siesjö
Mar 1, 1983·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T OkabeK Mortel
Mar 1, 1983·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P A SteenJ D Michenfelder
Jun 1, 1983·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E KågströmB K Siesjö
Jun 1, 1983·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E KågströmB K Siesjö
Jun 1, 1983·Experimental Neurology·B T StokesG Hollinden
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·F HirataJ Axelrod
Mar 1, 1980·Stroke; a Journal of Cerebral Circulation·D M Jarrott, F R Domer
Apr 1, 1982·Neurochemical Research·K KogureK Abe

❮ Previous
Next ❯

Citations

Jan 1, 1992·Journal of Neurosurgery·E D Hall
May 1, 1992·International Ophthalmology·S A CruzG A Peyman
Nov 14, 1994·Annals of the New York Academy of Sciences·W YoungS Constantini
Sep 24, 1999·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·R K KoçM Meral
Mar 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E D HallK L Linseman
Nov 1, 1992·Stroke; a Journal of Cerebral Circulation·J A OostveenL R Williams

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.