The Effects of Leptin Replacement on Neural Plasticity

Neural Plasticity
Gilberto Jorge Paz-Filho

Abstract

Leptin, an adipokine synthesized and secreted mainly by the adipose tissue, has multiple effects on the regulation of food intake, energy expenditure, and metabolism. Its recently-approved analogue, metreleptin, has been evaluated in clinical trials for the treatment of patients with leptin deficiency due to mutations in the leptin gene, lipodystrophy syndromes, and hypothalamic amenorrhea. In such patients, leptin replacement therapy has led to changes in brain structure and function in intra- and extrahypothalamic areas, including the hippocampus. Furthermore, in one of those patients, improvements in neurocognitive development have been observed. In addition to this evidence linking leptin to neural plasticity and function, observational studies evaluating leptin-sufficient humans have also demonstrated direct correlation between blood leptin levels and brain volume and inverse associations between circulating leptin and risk for the development of dementia. This review summarizes the evidence in the literature on the role of leptin in neural plasticity (in leptin-deficient and in leptin-sufficient individuals) and its effects on synaptic activity, glutamate receptor trafficking, neuronal morphology, neuronal development and...Continue Reading

References

Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·N GhilardiR C Skoda
Mar 21, 1998·Nature Genetics·A StrobelA D Strosberg
Feb 15, 2001·Dementia and Geriatric Cognitive Disorders·D A PowerD O'Neill
Nov 20, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·S MargeticR A Hill
Apr 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Julio LicinioMa-Li Wong
Apr 28, 2004·Diabetes·William A BanksJohn E Morley
May 29, 2004·Endocrinology·V C RussoG A Werther
Aug 21, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Neeraj K SaxenaFrank A Anania
Feb 17, 2005·The Journal of Clinical Endocrinology and Metabolism·John A MatochikJulio Licinio
Nov 19, 2005·Peptides·Susan A FarrJohn E Morley
Nov 2, 2006·Journal of Neurochemistry·Jenni Harvey
Jul 10, 2007·Molecular and Cellular Neurosciences·Dervla O'MalleyJenni Harvey
Aug 11, 2007·Science·I Sadaf FarooqiPaul C Fletcher
Nov 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Kate BaicyJulio Licinio
Nov 21, 2007·Current Opinion in Pharmacology·Jenni Harvey
Mar 25, 2008·Neurobiology of Aging·Karen F HoldenUNKNOWN Health ABC study
Sep 5, 2008·PloS One·Gilberto J Paz-FilhoJulio Licinio
Jan 10, 2009·Biochimica Et Biophysica Acta·Christopher D Morrison
Feb 13, 2009·The American Journal of Clinical Nutrition·I Sadaf Farooqi, Stephen O'Rahilly
Dec 17, 2009·JAMA : the Journal of the American Medical Association·Wolfgang LiebSudha Seshadri
Mar 20, 2010·European Journal of Endocrinology·Jacques BeltrandClaire Lévy-Marchal
Apr 13, 2010·The Journal of Clinical Endocrinology and Metabolism·Pamela Fischer-PosovszkyMartin Wabitsch
Apr 20, 2010·Brain Research·Sebastien G Bouret
Apr 22, 2010·JAMA : the Journal of the American Medical Association·Gilberto Paz-FilhoJulio Licinio
Nov 13, 2010·International Journal of Clinical Practice·G Paz-FilhoJ Licinio
Nov 19, 2010·Arquivos brasileiros de endocrinologia e metabologia·Jose DonatoCarol Fuzeti Elias
Dec 29, 2010·Journal of Alzheimer's Disease : JAD·Rui ZhouYan-Jiang Wang
Mar 18, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·G Paz-FilhoJ Licinio
May 20, 2011·Journal of Alzheimer's Disease : JAD·Ian A ClarkBryce Vissel
May 27, 2011·The Journal of Clinical Endocrinology and Metabolism·Edythe D LondonJulio Licinio
Aug 23, 2011·International Journal of Pediatric Obesity : IJPO : an Official Journal of the International Association for the Study of Obesity·Warda FatimaSaqib Mahmood
Nov 10, 2011·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Jean L ChanPhillip Gorden
Jan 19, 2012·International Journal of Alzheimer's Disease·Dayne Beccano-Kelly, Jenni Harvey
May 12, 2012·The Cerebellum·Steven M BermanEdythe D London

❮ Previous
Next ❯

Citations

Jan 14, 2018·BMC Cardiovascular Disorders·Clarisse Mourão Melo PonteRenan Magalhães Montenegro Júnior
Jan 26, 2018·European Journal of Human Genetics : EJHG·David Araújo-VilarSofía Sánchez-Iglesias
Sep 4, 2019·Obesity·Polyxeni KarakostaLida Chatzi
Dec 19, 2017·Global Heart·Jeffrey I MechanickW Timothy Garvey
Feb 19, 2020·Journal of Neurochemistry·Carmen Hierro-BujalanceMonica Garcia-Alloza
Apr 24, 2020·The European Journal of Neuroscience·Pasquale PiconeDomenico Nuzzo
Feb 9, 2020·Lipids in Health and Disease·Francky Teddy EndombaJoel Noutakdie Tochie
Jun 8, 2018·Hormones : International Journal of Endocrinology and Metabolism·Kristy L Meadows
May 1, 2021·Journal of Clinical Medicine·Sofía Sánchez-IglesiasDavid Araújo-Vilar

❮ Previous
Next ❯

Methods Mentioned

BETA
Replacement Therapy

Software Mentioned

NEPSY
Myalept

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Alzheimer's Disease: Microglia

Microglia are a type of glial cell found throughout the brain and spinal cord. Microglia have been found to be associated with Alzheimer's disease development and progression. Here are the latest discoveries pertaining to Alzheimer's disease and microglia.

Related Papers

Metabolism: Clinical and Experimental
Gilberto Jorge Paz-FilhoJulio Licinio
The American Journal of Clinical Nutrition
Susann Blüher, Christos S Mantzoros
Therapeutics and Clinical Risk Management
Alexander J RodriguezGilberto J Paz-Filho
Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research
Susan BlüherChristos S Mantzoros
Metabolism: Clinical and Experimental
Hyeong-Kyu Park, Rexford S Ahima
© 2022 Meta ULC. All rights reserved