Abstract
Animals attain information about their environment through different sense organs. For example, the dominant external resource about the environment for rodents is obtained through olfaction. Many environmental conditions (stress or enriched environment) are known to affect an animal's susceptibility to drug addiction. However, it is not known how external information is integrated and paired with drug stimuli to develop into addictive behavior. Here, we investigated the effects of olfactory epithelium lesions induced with ZnSO4 effusion (ZnE) on morphine-induced sensitization and conditioned place preference in mice. We found that the lesion of the olfactory epithelium attenuated the repeated morphine (40 mg/kg)-induced behavioral sensitization and morphine-induced conditioned place preference (CPP) behaviors, such as hyper-locomotion during morphine (40 mg/kg) conditioned training. Additionally, the expression of FosB-like proteins, transcription factors associated with behavioral alterations, in the nucleus accumbens of the brain was attenuated in morphine administered mice treated by ZnE. Taken together, these results indicated that lesion of the olfactory epithelium lead to a decrease in morphine sensitization and CPP beha...Continue Reading
References
Jan 1, 1991·Psychopharmacology·P E PaulsonT E Robinson
Feb 1, 1989·Pharmacology, Biochemistry, and Behavior·P VezinaJ Stewart
Jan 1, 1988·Psychopharmacology·T S ShippenbergA Herz
Jun 1, 1986·Brain Research·T E Robinson, J B Becker
Jul 1, 1995·Physiology & Behavior·I M van RijzingenB M Spruijt
Aug 2, 2001·Journal of Neural Transmission·J A Boening
Nov 26, 2002·Behavioural Brain Research·Gaetano Di Chiara
Nov 25, 2003·Chemical Senses·Kathleen McBrideFrank L Margolis
May 22, 2004·Neural Plasticity·B Ribeiro Do CoutoJ Miñarro
Nov 15, 2005·The Journal of Reproduction and Development·Gabriela Sánchez-AndradeKeith M Kendrick
Jan 18, 2006·Nature Neuroscience·Venetia ZachariouEric J Nestler
Feb 18, 2006·Chemical Senses·Matthieu KellerJulie Bakker
Mar 3, 2007·Experimental Neurology·Zhiwei XuChenggang Zhang
Mar 14, 2007·British Journal of Pharmacology·L CordonnierF Noble
Jun 23, 2007·BMC Neuroscience·Michael R TilleyHoward H Gu
Aug 7, 2007·Addiction Biology·Thomas M Tzschentke
Apr 15, 2008·Behavioural Brain Research·Wojciech SoleckiRyszard Przewlocki
May 24, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Mariana Bendlin CalzavaraRoberto Frussa-Filho
Jul 22, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Eric J Nestler
Feb 3, 2009·Psychopharmacology·Behnaz EsmaeiliAhmad Reza Dehpour
Dec 26, 2009·Biological Psychiatry·Oz MalkesmanHusseini K Manji
May 5, 2010·Journal of Neurochemistry·Cristina NúñezM Victoria Milanés
May 18, 2010·Nature Neuroscience·Vincent VialouEric J Nestler
Feb 23, 2011·Psychopharmacology·Thierry Le MarecNicolas Marie
Sep 3, 2011·PloS One·Gary B KaplanMarsha D Guy
Citations
Sep 30, 2014·Peptides·Richard J Bodnar
Jun 6, 2013·Biological Psychiatry·Amanda K FakiraJose A Morón
Oct 30, 2012·Pharmacology, Biochemistry, and Behavior·Haichen NiuHao Lei
Sep 7, 2014·Behavioural Brain Research·Yanmei ChenJianhong Wang
May 29, 2018·BioMed Research International·Haichen NiuQiang Zhang