The Effects of Leukocyte Filtration on Cell Salvaged Autologous Blood Transfusion on Lung Function and Lung Inflammatory and Oxidative Stress Reactions in Elderly Patients Undergoing Lumbar Spinal Surgery

Journal of Neurosurgical Anesthesiology
Lili XuZhiyong Hu

Abstract

This study was designed to investigate the effects of leukocyte filtration of autologous salvaged blood on lung function, lung inflammatory reaction, and oxidative stress reaction in elderly patients undergoing lumbar spinal surgery. Sixty elderly patients undergoing lumbar spinal surgery were randomly divided into 2 groups: Leukocyte Filter group and Control group. Serum levels of inflammatory markers including white blood cell and polymorphonuclear count, neutrophil elastase, serum surfactant protein A, methane dicarboxylic aldehyde, superoxide dismutase, interleukin (IL)-6, IL-8, tumor necrosis factor-α, and respiratory function markers including dynamic respiratory system compliance, oxygenation index, and respiratory index were measured immediately before induction of anesthesia (T0), immediately before blood transfusion (T1), and 1 (T2), 6 (T3), and 12 hours (T4) after end of blood transfusion. The Leukocyte Filter group had higher dynamic respiratory system compliance at T2, oxygenation index at T2 and T3, respiratory index and superoxide dismutase at T2, T3, and T4 than those in the Control group (P<0.05). The Leukocyte Filter group had lower white blood cell, polymorphonuclear count, neutrophil elastase, serum surfacta...Continue Reading

References

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Mar 1, 2017·Medical & Biological Engineering & Computing·Gaetano PerchiazziGöran Hedenstierna

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Citations

Jan 10, 2019·Current Opinion in Anaesthesiology·Anna Clebone
Jan 24, 2020·Journal of Neurosurgical Anesthesiology·Jeffrey J Pasternak
Mar 1, 2019·Current Opinion in Anaesthesiology·Anna Clebone
Oct 23, 2019·Korean journal of anesthesiology·Byung-Gun Lim, Il-Ok Lee

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Methods Mentioned

BETA
enzyme linked immunosorbent assay
MDA

Software Mentioned

SPSS

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