The effects of levosimendan on [Ca2+]i in guinea-pig isolated ventricular myocytes

European Journal of Pharmacology
M K Lancaster, S J Cook

Abstract

Ca2+-sensitising agents offer a new approach to the treatment of congestive heart failure. This study examined the effects of the Ca2+-sensitising agent, levosimendan, on contraction and [Ca2+]i in guinea-pig ventricular myocytes. Levosimendan 100 nM produced an increase in cell shortening without affecting the [Ca2+]i transient or the Ca2+ content of the sarcoplasmic reticulum. 1 microM levosimendan increased the rate of decay of the [Ca2+]i transient and increased the Ca2+ content of the sarcoplasmic reticulum. These results suggest that at therapeutically relevant concentrations levosimendan can produce a significant inotropic effect without affecting [Ca2+]i but at higher concentrations may also inhibit phosphodiesterase.

References

Nov 1, 1978·The American Journal of Physiology·E Page
Apr 1, 1993·Pflügers Archiv : European journal of physiology·A VarroD A Eisner
Sep 1, 1995·Journal of Molecular and Cellular Cardiology·H HaikalaI B Lindén
Aug 1, 1996·Circulation Research·C J Grantham, M B Cannell
Jan 1, 1995·Journal of Cardiovascular Pharmacology·E P SandellP J Pentikainen

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Citations

Feb 3, 2006·Cardiovascular Drugs and Therapy·Klara BrixiusRobert H G Schwinger
Jun 28, 2001·European Journal of Pharmacology·J LevijokiH Haikala
Jul 23, 2002·Lancet·F FollathUNKNOWN Steering Committee and Investigators of the Levosimendan Infusion versus Dobutamine (LIDO) Study
Dec 3, 2014·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·Nuno MorenoAdelino F Leite-Moreira
Mar 17, 2007·Pharmacology & Therapeutics·Charalambos AntoniadesChristodoulos Stefanadis
Apr 19, 2013·Journal of Clinical Pharmacy and Therapeutics·A PathakF Despas
May 4, 2005·Cardiovascular Drug Reviews·Zoltán PappIstván Edes
Jul 12, 2005·Expert Opinion on Investigational Drugs·Leif Erhardt
Sep 27, 2005·The American Journal of Cardiology·Mihai GheorghiadeAlexandre Mebazaa
Apr 16, 2004·Journal of Cardiovascular Pharmacology·Petri KaheinenHeimo Haikala
Jul 7, 2018·Pulmonary Circulation·Mona Sahlholdt HansenJens Erik Nielsen-Kudsk
Jul 27, 2007·American Journal of Hematology·Kürşat KaptanErsoy Işik
Aug 19, 2009·European Journal of Anaesthesiology·Annette D RiegGereon Schälte
Sep 14, 2007·Acta Anaesthesiologica Scandinavica·F GuarracinoC Vullo
Aug 24, 2005·Journal of Cardiovascular Pharmacology·E GrossiniG Vacca
May 23, 2001·Drugs·D P FiggittK L Goa
Mar 2, 2006·Anesthesiology·Wolfgang G Toller, Christian Stranz
Mar 12, 2009·Journal of Cardiovascular Pharmacology·Markku S NieminenZoltán Papp
Jul 30, 2019·Journal of Cardiovascular Pharmacology·Zoltán MártonJulius Gy Papp
May 3, 2014·Journal of Cardiovascular Pharmacology·László NagyZoltán Papp
Nov 6, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Patricia N BanforRyan M Fryer
Dec 1, 2019·Critical Care : the Official Journal of the Critical Care Forum·Bernard CholleyAlexandre Mebazaa
Dec 19, 2007·Anaesthesia and Intensive Care·P E SoedingJ A Angus
Jul 2, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Véronique Deschodt-ArsacPhilippe Diolez
May 10, 2017·Journal of the Chinese Medical Association : JCMA·Hsieh-Chou HuangChin-Chen Wu

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