PMID: 20626222Jul 16, 2010Paper

The effects of lidocaine on bupivacaine-induced cardiotoxicity in the isolated rat heart

Physiological Research
I KrikavaP Sevcík

Abstract

Bupivacaine is a widely used long-acting local anaesthetic. In clinical practice, a mixture of bupivacaine and lidocaine is often used in order to combine the faster onset of sensory blockade of lidocaine with more profound and longer duration of blockade by bupivacaine. The aim of this study was to compare the cardiotoxicity of large doses of bupivacaine and mixture of bupivacaine with lidocaine in the isolated rat heart and to estimate whether or not the addition of lidocaine in clinically relevant concentration increases bupivacaine-induced toxicity. Experiments were performed on 21 adult male rats divided into three groups: B (6 microg/ml bupivacaine), BL (6 microg/ml bupivacaine and 12 microg/ml lidocaine) and L (12 microg/ml lidocaine). The experiment consisted of three 30 min periods: stabilisation, perfusion and washout. The isolated hearts were perfused according to Langendorff with Krebs-Henseleit solution at constant pressure (80 mmHg) and 37 degrees C (CaCl(2) 1.25 mM) and the heart rate (based on RR interval assessment), PQ and QRS intervals were measured. The present study shows that the mixture of tested anaesthetics - bupivacaine and lidocaine - impairs the intraventricular conduction parameters (QRS interval pr...Continue Reading

Citations

Apr 10, 2013·The Journal of International Medical Research·Yinghan SongDongyang Ma
Aug 4, 2016·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Мarko J Milosavljevic, Slobodan M Jankovic
Jun 1, 2011·Hernia : the Journal of Hernias and Abdominal Wall Surgery·L-J BanW Zhang
Dec 18, 2014·Anesthesia and Analgesia·Petr StouracJiri Jarkovsky

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