The effects of lifetime food restriction on the development of osteoarthritis in the canine shoulder

Veterinary Surgery : VS
Jeffrey J RungeGail K Smith

Abstract

To report effects of age and lifetime food restriction on development and progression of shoulder joint osteoarthritis (OA) in Labrador retriever dogs. Longitudinal life-span, cohort study. Labrador retriever dogs (n=48). Littermates were paired (gender, weight) to make 24 pairs of genetically similar dogs. Each diet-restricted (DR) pair-mate was fed daily 75% of the same diet consumed by its control-fed (CF) pair-mate for life. Shoulders were evaluated radiographically at years 6, 8, and end of life (EOL). At EOL shoulders were evaluated grossly and by histopathology for OA. Radiographic evidence of shoulder OA was identified in 78% of dogs. Severity of radiographic shoulder OA at 6 (P<.03) and 8 years (P<.02) was significantly lower among DR dogs compared with CF dogs. Pooled gross evaluation results revealed 40 of 46 dogs had cartilage erosion on the caudal aspect of the humeral head. By EOL, 91% of dogs had histopathologic changes consistent with OA. There was a high overall prevalence of radiographic, gross, and histologic OA among dogs. Substantial disparity was found between radiographic evidence of OA (at EOL) and characteristic changes visible by gross and histologic examination. Radiographic evaluation correlates poor...Continue Reading

References

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Sep 5, 2006·Journal of the American Veterinary Medical Association·Gail K SmithRichard D Kealy

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Citations

Apr 28, 2016·Veterinary Surgery : VS·Zoe BelshawRachel S Dean
Jul 15, 2016·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Dennis LawlerGail Smith
Mar 3, 2010·Journal of Feline Medicine and Surgery·B Duncan X Lascelles, Sheilah A Robertson
Jul 10, 2012·Veterinary Pathology·L E Craig, A Reed
Jan 1, 2014·Canine Genetics and Epidemiology·Carys A PughDylan N Clements
May 16, 2020·Frontiers in Veterinary Science·Katharine L AndersonLisa M Collins
Apr 7, 2019·Nature Reviews. Rheumatology·Richard L MeesonAndrew A Pitsillides

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