PMID: 11917201Mar 28, 2002Paper

The effects of lipid-lowering therapy on low-density lipoprotein auto-antibodies: relationship with low-density lipoprotein oxidation and plasma total antioxidant status

Coronary Artery Disease
Cihan OremBirgül Vanizor Kural

Abstract

Oxidized low-density lipoprotein (Ox-LDL) is believed to play an important role in the progression of atherosclerosis. Oxidative modification of low-density lipoprotein (LDL) is a prerequisite for rapid accumulation of LDL in macrophages and for the formation of foam cells. Because of high antioxidant levels in plasma, LDL oxidation is suggested to occur mainly in the subendothelial space of the arterial wall, where there is the concomitant presence of large amounts of reactive oxygen species generated by endothelial cells and activated leukocytes. After Ox-LDL formation, antibodies against this form of LDL may occur. Auto-antibodies against Ox-LDL (AuAb-Ox-LDL) show directly in in-vivo LDL oxidation. Many studies have indicated that the amount of antibodies in serum is positively correlated to the rate of progression of atherosclerotic plaques. In this study the effect of lipid-lowering therapy on the levels of AuAb-Ox-LDL in patients with dyslipidemia was determined using atorvastatin (10 mg/day), and the relationship between the antibodies and plasma total antioxidant status (TAS) and LDL oxidation capacity was also investigated. Serum levels of AuAb-Ox-LDL, lipids, lipoproteins, TAS and susceptibility of LDL to oxidation we...Continue Reading

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Citations

Jul 7, 2011·Vascular Health and Risk Management·Ebru Demirel SezerTaner Onat
Sep 16, 2014·Diabetes & Metabolic Syndrome·Eugenia HoppsGregorio Caimi
May 17, 2011·European Journal of Internal Medicine·Murat KoksalTevfik Sabuncu
Dec 15, 2010·Medicina clínica·Juan Francisco Sánchez Muñoz-TorreroAlberto Costo
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May 22, 2010·Annals of Medicine·Christopher P F Marinangeli, Peter J H Jones
Mar 26, 2003·Coronary Artery Disease·Edgar R MillerJerilyn K Allen

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