The effects of lithium on muscle contractile function in humans

Muscle & Nerve
M A TarnopolskyK Winegard

Abstract

A side effect of lithium (Li+) treatment is fatigue. Li+ decreases inositol triphosphate (IP3) accumulation and IP3 may play a role in excitation-contraction (E-C) coupling in skeletal muscle. Li+ carbonate (600 mg b.i.d. x 6 days) was administered in a randomized, double-blind fashion to 12 males to measure the effect upon muscle contractile function: peak twitch torque (PTT), time to PTT, half-relaxation time, maximal voluntary contraction strength (MVC), percent motor unit activation, M-wave characteristics, and tetanic torque (3 min at 15 and 50 Hz). Li+ resulted in a significant decrease in 15- and 50Hz tetanic torque (P<0.00l), MVC, and resting PTT (P<0.05). There were no effects of Li+ upon any of the other measured variables. Li+ had a negative effect upon E-C coupling and did not affect central motor unit recruitment. Elucidation of the role of IP3 in E-C coupling may help to understand fatigue in some neuromuscular disorders.

References

Nov 1, 1977·The Journal of Physiology·R H EdwardsP A Merton
Jan 1, 1992·European Journal of Applied Physiology and Occupational Physiology·C M CupidoJ Martin
Dec 1, 1992·Journal of Applied Physiology·C A Lucidi, S L Lehman
Mar 1, 1992·Muscle & Nerve·S H Horowitz, C Krarup
Mar 1, 1992·Muscle & Nerve·R S MoussaviR G Miller
Mar 1, 1990·Pflügers Archiv : European journal of physiology·H WesterbladD G Allen
Sep 21, 1989·Nature·M J Berridge, R F Irvine
Jul 1, 1989·The Journal of Physiology·A Hicks, A J McComas
Feb 1, 1988·The Biochemical Journal·N S GeeJ K Shute
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J VergaraM Delay
May 1, 1986·The American Journal of Physiology·T M NosekR E Godt
Oct 1, 1988·Journal of Applied Physiology·M Bergström, E Hultman
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S K DonaldsonD A Huetteman
Jan 19, 1987·Biochimica Et Biophysica Acta·S K DonaldsonD A Huetteman
Nov 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·A Y Belanger, A J McComas

❮ Previous
Next ❯

Citations

Apr 13, 2010·Doklady. Biochemistry and Biophysics·S M KorotkovI V Brailovskaya

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.