PMID: 6983179Jan 1, 1982Paper

The effects of local anaesthetics on retinal function

Vision Research
L M Rapp, S Basinger

Abstract

Isolated frog eyecups were incubated in Ringer containing local anaesthetics to study the effects of these drugs on dark-adaptation of the ERG. Relative to controls, dark-adaptation in eyecups treated with millimolar concentrations of MS-222, benzocaine, and procaine HCl was significantly inhibited during 10 to 120 min following the cessation of the adapting light. These drugs also prevented the recovery of the c-wave during dark-adaptation, resulting in ERG waveforms resembling those found in light-adapted eyecups. Measurements of rhodopsin in the retina were consistent with previous findings showing that rhodopsin regeneration in situ is inhibited by local anaesthetics. In vitro regeneration experiments in which bleached rod outer segment fragments were added to 11-cis retinal showed that preincubation of retinal with MS-222 in ethanol prevents rhodopsin regeneration. Evidence was obtained spectrophotometrically for the formation of a complex between MS-222 and 11-cis retinal with a gamma max of 512 nm. We propose that the formation of a Schiff's base between these two compounds blocks the recombination of rhodopsin, and in situ, leads to the inhibition of dark-adaptation.

References

Sep 1, 1975·European Journal of Pharmacology·D T Frazier, T Narahashi
Mar 1, 1977·Canadian Anaesthetists' Society Journal·A P WinnieK Z Masud
Feb 1, 1977·Vision Research·R Hoffman, S Basinger
May 21, 1974·Biochemistry·D S Papermaster, W J Dreyer
Jan 1, 1969·UCLA Forum in Medical Sciences·K T Brown
Jan 1, 1967·Vision Research·K O Donner, T Reuter
Jul 8, 1967·Nature·G W WeinsteinJ E Dowling
Oct 1, 1959·The Journal of Physiology·M G FUORTES
Jul 1, 1963·The Journal of General Physiology·J E DOWLING
Nov 1, 1964·The Journal of General Physiology·M B FEINSTEIN

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Citations

Feb 1, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·C J LaytonN N Osborne
Jan 1, 1991·Journal of Photochemistry and Photobiology. B, Biology·G J Fowler, R Devonshire
May 21, 2013·Journal of the American Veterinary Medical Association·Kate M BaileyLysa P Posner
Dec 24, 1997·American Journal of Ophthalmology·P S BernsteinD J Creel
Jun 5, 2004·Progress in Retinal and Eye Research·T D Lamb, E N Pugh
Jan 31, 2015·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Kate M BaileyLysa P Posner
Oct 11, 1984·Nature·S J FlieslerJ G Hollyfield

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