The effects of local anesthetic containing adrenaline on gingival blood flow in smokers and non-smokers

Journal of Clinical Periodontology
M Ketabi, R S Hirsch

Abstract

Recent evidence suggests that fundamental differences exist in the development of gingival and periodontal diseases in smokers versus non-smokers. In part, these differences may be attributable to smoking-induced differences in the vascular dynamics of the periodontium. This study monitored gingival blood flow when challenged by a local anesthetic-containing adrenaline in 20 smokers and 20 non-smokers using laser Doppler flowmetry (LDF). The dosage of local anesthetic used (0.5 ml lignocaine hydrochloride 2% with adrenaline 1:80,000) was calculated after establishing a dose-response curve (DRC) for 3 subjects (2 non-smokers and 1 smoker). Plain lignocaine and normal saline were used as controls. The injection of lignocaine-containing adrenaline had little effect on LDF signals when different doses were injected at frequent short intervals, indicating that tolerance to adrenaline had rapidly developed in the receptors of gingival blood vessels. Injection of local anesthetics containing adrenaline consistently resulted in a marked and significant drop (average: 46%, sd;13.5) in the LDF output signals from gingiva; smokers and non-smokers responded similarly. The significant finding of this study was that the recovery of LDF signa...Continue Reading

References

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Citations

Mar 16, 2002·Journal of Clinical Periodontology·Pascal AmbrosiniJacques Penaud
Oct 23, 2002·Journal of Clinical Periodontology·Gloria CalsinaJosé-Javier Echeverría
Jan 13, 2001·Journal of Periodontology·T HaniokaS Shizukuishi
Oct 13, 2006·Journal of Periodontology·Christiane GleissnerBrita Willershausen
Dec 30, 2010·Journal of Periodontology·Juliano Milanezi de AlmeidaValdir Gouveia Garcia
Jan 12, 2005·Journal of Clinical Periodontology·Nurcan BuduneliGunnar Dahlen
Apr 7, 2005·Journal of Clinical Periodontology·Nurcan BuduneliDenis F Kinane
May 23, 2009·International Endodontic Journal·H Jafarzadeh
Mar 16, 2004·Journal of Clinical Periodontology·Toshiya MorozumiHiromasa Yoshie
Mar 13, 2003·Journal of Clinical Periodontology·Antonios MavropoulosPål Brodin
Apr 24, 2007·Journal of Clinical Periodontology·M RetzepiN Donos
Aug 30, 2008·Journal of Clinical Periodontology·Nurcan BuduneliDavid F Lappin
Aug 29, 2013·The EPMA Journal·Liudmila Yu Orekhova, Anna A Barmasheva
Feb 20, 2018·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Réka FazekasJános Vág
Apr 2, 2004·Journal of Endodontics·Kerem Engin AkpinarNilüfer Tülin Polat

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