PMID: 3752545Jul 1, 1986Paper

The effects of long-term colchicine therapy on male fertility in patients with familial Mediterranean fever

Andrologia
M EhrenfeldM Eliakim

Abstract

Four out of 19 male patients suffering from familial Mediterranean fever (FMF) had fertility problems while on colchicine therapy (0.5-2.0 mg daily for as long as 11 years). Three of the patients had had children while off therapy but their wives could not conceive while they were on therapy. In one patient primary sterility remained one year after cessation of colchicine. In this and two other patients the spermiogram was normal but the sperm penetration test was pathological. The fourth patient had azoospermia. Patients should be informed about this possible risk of colchicine therapy. The need for continued follow-up and the value of the sperm penetration test in the detection of fertility problems in male patients on long-term colchicine therapy are stressed. It is concluded however, that overall the benefits outweigh the danger of long-term colchicine treatment in male patients with FMF.

References

Sep 24, 1977·British Medical Journal·M Levy, M Eliakim
Jun 17, 1976·The New England Journal of Medicine·W J Bremner, C A Paulsen
Mar 1, 1972·Fertility and Sterility·H E Merlin
Sep 1, 1983·Fertility and Sterility·E J MargaliothJ G Schenker

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Citations

Oct 1, 1990·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Y Shimoni, E Shalev
Apr 15, 2010·Genetics and Molecular Research : GMR·E O EtemA Arslan
Aug 6, 2015·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Nicholas C Schwier
Nov 5, 2016·Annals of the Rheumatic Diseases·Nienke M Ter HaarJoost Frenkel
Jun 1, 1991·Arthritis and Rheumatism·L W Moreland, G V Ball
Dec 1, 1987·British Journal of Obstetrics and Gynaecology·M EhrenfeldM Eliakim
Dec 1, 1991·Seminars in Arthritis and Rheumatism·C PuttermanM Levy
Dec 1, 1996·Seminars in Arthritis and Rheumatism·A LivnehM Pras

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