Apr 1, 1989

The effects of long term Tranilast administration on bronchial hypersensitivity in asthmatics

Panminerva Medica
H SuzukiE Noguchi

Abstract

Tranilast is an oral antiallergic agent developed in Japan. This study investigated the effect of prolonged administration of Tranilast on the bronchial sensitivity of 18 asthmatic subjects. They were treated for either less than 3 months or more than 3 months continuously. Methacholine loading testing was used to assess bronchial reactivity, and the respiratory parameters were recorded on an Astograph. Patients treated for longer than 3 months showed a significant decrease in bronchial sensitivity (p less than 0.05). The anticholinergic and bronchodilatory properties of Tranilast were also investigated in 8 subjects. No significant anticholinergic or bronchodilatory effects were observed following a single oral dose of 100 mg of Tranilast.

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Mentioned in this Paper

Bronchial System
Immediate Hypersensitivity
Bronchial Provocation Tests
Anticholinergic [EPC]
Illusions
Drug Evaluation
Asthma
Bronchial brand of guaifenesin-theophylline
Bronchial Specimen
Methacholine

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