The effects of low-dose endotoxin on the umbilicoplacental circulation in preterm sheep

Journal of the Society for Gynecologic Investigation
Audrey B C CoumansTom H M Hasaart

Abstract

In the present study we examined the effects of low-dose endotoxin (lipopolysaccharides, LPS) on continuously recorded umbilical blood flow. Twenty fetal sheep were catheterized at a gestational age of 107 +/- 1 days. A flow probe was placed around either the common umbilical artery or one single umbilical artery. Three days later fetuses received either 100 or 500 nanograms of LPS (n = 14) or 2 mL saline (n = 6) intravenously. Six fetuses died within 12 hours after LPS. Fetal heart rate (FHR), mean arterial pressure (MAP), and umbilical blood flow (Q(umb)) were monitored for 3 days. FHR increased by 25 +/- 4% at 4-5 hours after LPS (P <.01) and was elevated for 15 hours after LPS. MAP increased by 18 +/- 5% 1 hour after LPS (P <.01) and returned to control value 4-5 hours after LPS. Q(umb) began to decrease 1 hour after LPS and was minimal (-30 +/- 7%, P <.001) at 4-5 hours after LPS. Q(umb) slowly returned to the control value at 12 hours after LPS. Placental vascular resistance increased by 73 +/- 37% (P <.01), whereas pH did not appreciably change. Intravenous application of endotoxin caused a substantial and long-lasting decrease in umbilical blood flow resulting in fetal hypoxemia without acidemia. These effects may be of...Continue Reading

References

Dec 3, 1991·European Journal of Pharmacology·T NakamuraS Shimoda
Jan 1, 1991·Journal of Cardiovascular Pharmacology·J M LundbergE Weitzberg
Apr 13, 1984·JAMA : the Journal of the American Medical Association·K B Nelson, J H Ellenberg
Sep 1, 1994·Journal of Applied Physiology·H LiT S Elton
Nov 18, 1997·JAMA : the Journal of the American Medical Association·K B Nelson, J K Grether
Sep 10, 1998·American Journal of Obstetrics and Gynecology·K B Nelson, J K Grether
Oct 26, 2000·European Journal of Pharmacology·M WanecekA Oldner
Apr 4, 2001·The European Journal of Neuroscience·S EklindH Hagberg
Nov 20, 2002·Pediatric Research·Jhodie R DuncanSandra M Rees

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Citations

Sep 3, 2010·American Journal of Epidemiology·Alan LevitonUNKNOWN ELGAN Study Investigators
Oct 12, 2010·Journal of Perinatology : Official Journal of the California Perinatal Association·M GantertB W Kramer
Sep 8, 2009·Clinics in Perinatology·Laura Bennet, Alistair Jan Gunn
Oct 19, 2007·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Yves GarnierBerthold Huppertz
Jan 3, 2006·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Yves GarnierDiego Gazzolo
Aug 2, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Yves GarnierTom H M Hasaart
Dec 8, 2010·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Israt JahanMohammad A Rashid
Feb 7, 2019·Journal of the Science of Food and Agriculture·Mekhala Dk VithanaStuart K Johnson
Jun 6, 2019·Revista da Associação Médica Brasileira·Ali MazouriMandana Kashaki
Jun 2, 2011·Pediatric Research·Matthias SeehaseBoris W Kramer

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