The effects of low-dose growth hormone in HIV-infected men with fat accumulation: a pilot study

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Joan C LoMorris Schambelan

Abstract

Pharmacologic doses of growth hormone (GH) reduce HIV-associated fat accumulation but may worsen glucose metabolism. We investigated the effects of a low dose of GH (1 mg per day) in HIV-infected men with fat accumulation and found that such treatment reduced total fat and increased lean body mass without significant changes in glucose tolerance or insulin sensitivity. Visceral adipose tissue (VAT) levels did not change significantly for the group as a whole, although a reduction in the VAT level was seen in patients with a greater VAT level at baseline.

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Citations

Aug 5, 2008·JAMA : the Journal of the American Medical Association·Janet LoSteven Grinspoon
Feb 14, 2008·Pituitary·Takara L Stanley, Steven K Grinspoon
Feb 23, 2008·The Journal of Clinical Investigation·Kiki Tesselaar, Frank Miedema
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Oct 4, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Giorgos K SakkasIoannis Stefanidis
May 22, 2010·Expert Opinion on Pharmacotherapy·Rajagopal V Sekhar, Ashok Balasubramanyam
Jul 11, 2006·The American Journal of Clinical Nutrition·Susana D'AmicoAshok Balasubramanyam

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