The effects of lung recruitment maneuvers on exhaled breath condensate pH

Journal of Breath Research
Brian K WalshJohn H Arnold

Abstract

Exhaled breath condensate (EBC) pH serves as a surrogate marker of airway lining fluid (ALF) pH and can be used to evaluate airway acidification (AA). AA is known to be present in acute respiratory distress syndrome (ARDS) and can be evaluated via continuous EBC pH measurement during mechanical ventilation. Lung recruitment maneuvers (LRMs) are utilized in the treatment of ARDS, however, their impact on EBC pH has never been explored. Here we described the acute effects of two commonly used LRMs on EBC pH. In a prospective, non-randomized, serial exposure study, 10 intubated pediatric subjects with acute respiratory distress syndrome sequentially underwent: a period of baseline ventilation, sustained inflation (SI) maneuver of 40 cm H2O for 40 s, open lung ventilation, staircase recruitment strategy (SRS) (which involves a systematic ramping of plateau pressures in 5 cm H2O increments, starting at 30 cm H2O), and PEEP titration. Maximum lung recruitment during the SRS is defined as a PaO2 + PaCO2 of  >400 mmHg. Following lung recruitment, PEEP titration was conducted from 20 cm H2O in 2 cm H2O decrements until a PaO2 + PaCO2 was  <380 and then increased by 2 cm H2O. EBC pH, arterial blood gases, lung mechanics, hemodynamics, an...Continue Reading

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Citations

Sep 25, 2019·International Journal of Molecular Sciences·Alexey S KononikhinEvgeny N Nikolaev
May 5, 2020·Technology and Health Care : Official Journal of the European Society for Engineering and Medicine·Jinliang ChenJianrong Chen
Oct 17, 2020·Journal of Breath Research·Michael D DavisAlison J Montpetit

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