The effects of malnutrition on secretory and cellular immune processes

CRC Critical Reviews in Food Science and Nutrition
R R Watson, D N McMurray

Abstract

About 15 million children under 5 years of age die each year due to suppressed immunity and the resulting increased infection. In severely malnourished children and animals some immune systems such as T-cell function, secretory IgA and complement are significantly suppressed. Other systems, such as the serum IgG or IgA, are normal or even elevated. Some of these changes are apparently caused by nutritional stress while others may be due to stimulation by increased incidence of infection and antigen load. On the other hand, marginal malnutrition stimulates increased phagocytosis and T-cell function with increased immunity to cancer but decreased resistance to certain microbial agents. The mechanisms of immune suppression by malnutrition, persistence of these effects after renutrition, and the effect of maternal malnutrition on newborn immunity are critically reviewed. Possible non-nutritional means of rapid immunological restoration of malnourished children are described.

References

Feb 1, 1975·The Journal of Experimental Medicine·R A Murgita, T B Tomasi
Jun 19, 1976·Lancet·S G SrikantiaK A Krishnamachari
Jan 1, 1977·International Archives of Allergy and Applied Immunology·R K Chandra, R A Bhujwala
Nov 19, 1977·Lancet·M H GoldenB E Golden
Apr 1, 1978·Hospital Practice·B Benacerraf
May 1, 1976·The Medical Clinics of North America·A L GoldsteinJ T Ulrich
May 1, 1976·Nutrition Reviews·R K Chandra
Jul 1, 1976·The American Journal of Clinical Nutrition·L SchlesingerA Stekel
Oct 1, 1976·The Journal of Clinical Investigation·C C WaddellJ J Twomey
Jul 1, 1977·The American Journal of Clinical Nutrition·P G Shilotri, K S Bhat
Apr 1, 1978·The American Journal of Clinical Nutrition·R G Strauss
Aug 1, 1977·The American Journal of Clinical Nutrition·W R Beisel
Sep 1, 1977·The American Journal of Clinical Nutrition·O Felsenfeld, K Gyr
Oct 1, 1977·The Journal of Tropical Pediatrics and Environmental Child Health·J E Brown, R C Brown
Oct 1, 1977·Archives of Internal Medicine·B R BistrianC Shaw
Feb 1, 1978·Proceedings of the Society for Experimental Biology and Medicine·R R WatsonD N McMurray
Dec 1, 1976·The Proceedings of the Nutrition Society·W P FaulkC Marigo
Feb 1, 1975·The American Journal of Clinical Nutrition·C G NeumannM Jacob
Mar 1, 1975·Archives of Disease in Childhood·R K Chandra
Jan 1, 1976·The American Journal of Clinical Nutrition·V ReddyS G Srikantia
Jan 1, 1976·Clinical Immunology and Immunopathology·S D Douglas, K Schopfer
Apr 1, 1976·The American Journal of Clinical Nutrition·R G Bell Sunoto
Mar 1, 1977·The American Journal of Clinical Nutrition·P KulapongsR E Olson
Apr 1, 1977·The American Journal of Clinical Nutrition·A A Kielmann
May 1, 1977·British Journal of Haematology·M A Horton, J F Burman
Jul 1, 1976·The American Journal of Clinical Nutrition·R GangulyR H Waldman
Sep 1, 1976·The Journal of Investigative Dermatology·H F DvorakA M Dvorak
Aug 1, 1976·Canadian Journal of Physiology and Pharmacology·H B GeigerA C Groom
Apr 24, 1975·The New England Journal of Medicine·K H Neldner, K M Hambidge
Sep 1, 1975·Scandinavian Journal of Clinical and Laboratory Investigation·B KjösenO Myking
Mar 1, 1975·The American Journal of Clinical Nutrition·R L GrossW Hift
Jun 1, 1975·The Journal of Pediatrics·R K Chandra, A K Saraya
Mar 1, 1975·Archives of Disease in Childhood·E U RosenA R Rabson
Oct 31, 1970·British Medical Journal·S ReddyH McFAarlane

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Citations

Jan 1, 1988·Medical Microbiology and Immunology·C L TetzlaffD N McMurray
Jan 1, 1986·International Journal of Immunopharmacology·R R Watson, T S Lim
Sep 26, 2001·Infectious Disease Clinics of North America·E L Pesanti
Jul 22, 1998·Community Dentistry and Oral Epidemiology·W K Seow
Feb 1, 1991·Archives of Disease in Childhood·A PrenticeP G Lunn
Mar 4, 1989·BMJ : British Medical Journal·F J Dunne
Mar 1, 1983·Pediatric Annals·J I SantosJ J Vitale
Aug 1, 1996·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·S SchneiderP Rampal
Jan 1, 1992·Journal of the American Geriatrics Society·D C Powers
Dec 13, 2006·Revista Da Sociedade Brasileira De Medicina Tropical·Carlos Fernández de LarreaZaida Araujo
Jan 1, 1982·JPEN. Journal of Parenteral and Enteral Nutrition·P TwomeyJ Rombeau
Jan 1, 1985·Journal of Dental Research·I JohanssonM Cole
Jul 19, 2006·Annals of Nutrition & Metabolism·Anna Kokavec, Simon F Crowe
Aug 1, 1986·Alcoholism, Clinical and Experimental Research·R R WatsonB Hartmann
May 1, 1985·Alcoholism, Clinical and Experimental Research·R R WatsonC Eskelson
Jan 1, 1991·Acta Paediatrica Scandinavica. Supplement·A Prentice
Dec 1, 1982·Pediatric Annals·G T Keusch
Jan 1, 1984·Critical Reviews in Microbiology·R R Watson, T M Petro
Jun 1, 1994·The American Journal of the Medical Sciences·W BoundsR F Holcombe

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