The effects of manganese on glutamate, dopamine and gamma-aminobutyric acid regulation

Neurochemistry International
Vanessa A FitsanakisMichael Aschner

Abstract

Exposure to high levels of manganese (Mn) results in a neurological disorder, termed manganism, which shares a similar phenotype to Parkinson's disease due to the involvement of the basal ganglia circuitry in both. The initial symptoms of manganism are likely due to the involvement of the globus pallidus, a region rich in gamma-aminobutyric acid (GABA) projections, while those of Parkinson's disease are related to the degeneration of the substantia nigra, a dopaminergic nucleus. Additionally, it is known that glutamate regulation is affected by increases in brain Mn levels. As Mn predominantly accumulates in the basal ganglia, it potentially could affect the regulation and interactions of all three neurotransmitters. This review will focus on the circuitry of these neurotransmitters within the basal ganglia and address potential sites for, as well as the temporal relationship, between Mn exposure and changes in the levels of these neurotransmitters. While most research has focused on perturbations in the dopaminergic system, there is evidence to support that early consequences of manganism also include disturbances in GABA regulation as well as glutamatergic-related excitotoxicity. Finally, we suggest that current research focu...Continue Reading

References

Jan 1, 1992·Archives of Toxicology·H ErikssonE Heilbronn
May 20, 1999·Annual Review of Pharmacology and Toxicology·M AschnerW J Streit
Nov 26, 1999·JPEN. Journal of Parenteral and Enteral Nutrition·K FitzgeraldR M Craig
Feb 2, 2000·Neuroscience and Biobehavioral Reviews·D ValloneE Borrelli
Jul 8, 2000·JPEN. Journal of Parenteral and Enteral Nutrition·D B BertinetF Balzola
Jan 13, 2001·Experimental Brain Research·F SpadoniG Sancesario
May 23, 2001·Progress in Neurobiology·N C Danbolt
Aug 8, 2002·Neurotoxicology·R H GwiazdaD R Smith
Dec 31, 2002·Brain Research. Brain Research Reviews·Atsushi Takeda
May 14, 2003·Neurochemistry International·Keith M Erikson, Michael Aschner
Jun 11, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Claudia ZwingmannAlan S Hazell
Jul 10, 2003·International Journal of Occupational and Environmental Health·Barry S Levy, William J Nassetta
Jan 1, 1955·British Journal of Industrial Medicine·J RODIER
Dec 4, 2003·Journal of Neurology·Chin-Chang HuangTzu-Chen Yen
Mar 6, 2004·Journal of Toxicology and Environmental Health. Part a·Sébastien BoltéJoseph Zayed
Jul 21, 2004·Journal of Synchrotron Radiation·T ResslerJ Roos
Oct 13, 2004·Environmental Research·Halina RöllinFrancois Wewers
Jan 14, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Brad A RacetteJoel S Perlmutter
Feb 5, 2005·Biological Psychiatry·E Fuller TorreyMichael B Knable
Nov 1, 2005·Environmental Toxicology and Pharmacology·Keith M EriksonMichael Aschner

❮ Previous
Next ❯

Citations

Aug 28, 2013·International Archives of Occupational and Environmental Health·Maria HedmerHåkan Tinnerberg
Sep 14, 2012·Biological Trace Element Research·Dinamene SantosA P Marreilha dos Santos
Jul 3, 2013·Biological Trace Element Research·Xiaofei LiuShi Wen Xu
Oct 25, 2011·Neuron Glia Biology·Jan AlbrechtMichael Aschner
Jan 12, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jason M WilliamsMalcolm J Avison
Mar 15, 2013·Current Opinion in Pediatrics·Silvia Zoni, Roberto G Lucchini
Apr 19, 2013·BMC Pharmacology & Toxicology·Marta Sidoryk-Wegrzynowicz, Michael Aschner
Mar 21, 2007·Environmental Health Perspectives·Maryse BouchardDonna Mergler
Jul 19, 2011·Metallomics : Integrated Biometal Science·Erika MitchellBibudhendra Sarkar
Nov 6, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christoffer TammSandra Ceccatelli
Aug 8, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·David C DormanAlan J Higgins
Jun 20, 2014·Environmental Toxicology·Talia SandersPaul B Tchounwou
Jan 25, 2011·The Mount Sinai Journal of Medicine, New York·Amir Miodovnik
Nov 13, 2012·Environmental Research·R Torres-AgustínC Ríos
Mar 6, 2013·European Journal of Pharmacology·Sanders A McDougallCynthia A Crawford
May 2, 2014·Food Additives & Contaminants. Part B, Surveillance·Ayenew Ashenef
Jun 20, 2008·Neurotoxicology·Maryse BouchardMichel Panisset
May 26, 2009·Neurotoxicology·Monika Meyer-BaronChristoph van Thriel
Jul 11, 2007·American Journal of Industrial Medicine·Melanie F StruveDavid C Dorman
Jun 16, 2009·Toxicology and Applied Pharmacology·Gennaro GiordanoLucio G Costa
Jan 9, 2010·Toxicology and Industrial Health·Zhaofa XuFanglin Zhang
Jul 15, 2015·International Journal of Environmental Research and Public Health·Gunnar F KwakyeMichael Aschner
Jul 8, 2010·Journal of Clinical Neurology·Yangho KimMyoung-Soon Oh
Oct 2, 2008·Biological & Pharmaceutical Bulletin·Jungmin Nam, Kisok Kim
Jun 30, 2009·Journal of Neurochemistry·Thaís PosserPeter R Dunkley
Jan 31, 2013·Journal of Internal Medicine·M Sidoryk-Wegrzynowicz, M Aschner
Feb 26, 2015·Pharmacological Reports : PR·Katarzyna MłyniecBogusława Budziszewska
Feb 21, 2014·Pharmacological Reports : PR·Małgorzata Kajta, Anna K Wójtowicz
Mar 20, 2020·The Journal of Biological Chemistry·Rekha C BalachandranAaron B Bowman
Aug 18, 2020·Expert Review of Neurotherapeutics·Airton C MartinsMichael Aschner
Sep 25, 2019·International Journal of Environmental Research and Public Health·Airton Cunha MartinsMichael Aschner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Astrocytes in Parkinson Disease

Parkinson's disease (PD) is a neurodegenerative disorder caused by the progressive loss of dopaminergic neurons. Some PD-genes may be associated with astrocyte dysfunction. Discover the latest research on astrocytes in Parkinson's disease here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Basal ganglia in Parkinson's disease (MDS)

The basal ganglia is comprised of the neostriatum, the external and internal pallidal segments, the subthalamic nucleus, the substantia nigra pars reticulata, and the pars compacta of the substantia nigra. The basal ganglia circuitry is responsible for the correct execution of voluntary movements and is implicated in Parkinson's disease. Here is the latest research investigating the basal ganglia in Parkinson's disease.