The effects of Maras powder (smokeless tobacco) on oxidative stress in users

Cell Biochemistry and Function
Metin KilincIlhami Yildirim

Abstract

Maras Powder (MP) is a special kind of smokeless tobacco widely used in the southeast region of Turkey especially in Kahramanmaras and Gaziantep and other southeastern cities. It is obtained from a tobacco species, Nicotiana rustica L and ash of oak or grapevine wood. Tobacco may increase oxidative stress, which is related to the products of the oxygen metabolism taking place in all cells. Cellular antioxidants, e.g. catalase (CAT), superoxide dismutase (SOD) and glucose 6-phosphate dehydrogenase (G6PD) protect the cell against oxidative damage. An imbalance between the ROS and antioxidants in favour of ROS is described as oxidative stress. In this study, we aimed to investigate the effect of MP on antioxidant enzyme levels and lipid peroxidation. We measured malondialdehyde (MDA), CAT, SOD and G6PD levels in blood of 68 MP users and 30 healthy controls who did not use MP. CAT, SOD and G6PD levels were lower in MP users than in the controls. On the other hand, lipid peroxidation levels (MDA), one of the best indicators of cytological damage, was increased in MP users compared with the controls. The present study showed that MP increases oxidative stress, which may cause many systemic disorders, including arteriosclerosis.

Citations

Feb 28, 2009·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Richard J Bloomer, Kelsey Fisher-Wellman
Oct 17, 2013·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Mustafa Haki SucakliOrhan Bozoglan
Nov 9, 2012·International Journal of Medical Sciences·Aytekin Guven, Fatma Tolun
Jun 17, 2015·Journal of Hand and Microsurgery·Tahsin Oğuz Acartürk
Sep 2, 2017·Diagnostic Cytopathology·Adile Ferda DagliSuleyman Aydin
Nov 11, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Pramod Kumar AvtiKrishan Lal Khanduja

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