PMID: 3670561Sep 1, 1987Paper

The effects of mazindol on local cerebral glucose utilization in rats

M KubotaS Yoshida


The effects of mazindol (1 mg or 10 mg/animal, p.o.) on local cerebral utilization of glucose were studied by the quantitative autoradiographic [14C]2-deoxyglucose method in conscious adult male rats. Significant increases in local cerebral utilization of glucose were observed 2 hr after administration of 10 mg of mazindol in 10 out of 37 anatomically discrete regions examined. These 10 areas included regions rich in dopaminergic receptors (substantia nigra, globus pallidus), and also regions with few dopaminergic receptors (cerebral cortex, thalamus, cerebellum). Only the habenular nucleus showed a significant decrease in utilization of glucose induced by the administration of 10 mg of mazindol. No significant changes in local cerebral utilization of glucose were observed following the administration of 1 mg of mazindol. The fact that the pattern of utilization of glucose observed in this study resembled that produced by apomorphine, a putative dopaminergic agonist, indicates that the pharmacological effects of mazindol are related to the dopaminergic system.


Jan 1, 1979·Journal of Neurochemistry·L R WechslerL Sokoloff
Apr 1, 1976·European Journal of Pharmacology·F ZambottiP Mantegazza
Jul 30, 1966·Nature·A Randrup, I Munkvad
Jul 30, 1984·Brain Research·G SkagerbergA Björklund
Jun 17, 1983·European Journal of Pharmacology·J A JavitchS H Snyder
Jan 1, 1970·Progress in Histochemistry and Cytochemistry·W Lichtensteiger

❮ Previous
Next ❯


Jan 1, 1989·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·J H CoakleyR H Edwards

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.