The Effects of Melatonin in Patients with Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial

Advanced Biomedical Research
Hassan PakravanBahram Pakzad

Abstract

This study was designed to evaluate the effect of melatonin on nonalcoholic fatty liver disease (NAFLD) in compared to placebo. A total of 100 patients with histopathological diagnosis NAFLD in two groups of case and control received oral melatonin or placebo thrice daily for 3 months. Collected data were weight, waist, systolic blood pressure (SBP), diastolic blood pressure (DBP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), high sensitive C-reactive protein (hsCRP), fatty liver grade, and side effects which were measured at baseline and after treatment period using standard clinical chemistry techniques. Before treatment the mean of weight, waist, SBP, DBP, ALT, AST, and hsCRP between cases and controls were similar (P > 0.5). After treatment, only the differences in the mean of hsCRP in cases was significantly lower than controls (P = 0.003). In case group, all variables after treatment were significantly decreased compare to baseline (P > 0.5) and only AST after treatment was similar to before treatment (P > 0.5). The mean of a decrease in the level of weight, waist, SBP, and ALT were not statistically significant between groups (P > 0.5). In the case group in compare to control group the level of DBP, ...Continue Reading

Citations

Aug 31, 2018·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Abbas Taghavi ArdakaniZatollah Asemi
Oct 21, 2018·Postgraduate Medical Journal·Kannan SridharanAbdelaziz Elamin
Sep 3, 2019·Journal of Cellular and Molecular Medicine·Chenxia HuLanjuan Li
Jan 28, 2021·Brain Sciences·Oana-Mihaela PlotogeaCamelia Cristina Diaconu
Feb 14, 2021·Brain, Behavior, and Immunity·Joshua H ChoMichael R Irwin
Aug 5, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yuval IshayYaron Ilan
Dec 4, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Claudia PivonelloAnnamaria Colao

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Methods Mentioned

BETA
biopsy

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SPSS
Random Allocation

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