The effects of membrane cholesterol and simvastatin on red blood cell deformability and ATP release

Microvascular Research
Alison M ForsythHoward A Stone

Abstract

It is known that deformation of red blood cells (RBCs) is linked to ATP release from the cells. Further, membrane cholesterol has been shown to alter properties of the cell membrane such as fluidity and bending stiffness. Membrane cholesterol content is increased in some cardiovascular diseases, for example, in individuals with acute coronary syndromes and chronic stable angina, and therefore, because of the potential clinical relevance, we investigated the influence of altered RBC membrane cholesterol levels on ATP release. Because of the correlation between statins and reduced membrane cholesterol in vivo, we also investigated the effects of simvastatin on RBC deformation and ATP release. We found that reducing membrane cholesterol increases cell deformability and ATP release. We also found that simvastatin increases deformability by acting directly on the membrane in the absence of the liver, and that ATP release was increased for cells with enriched cholesterol after treatment with simvastatin.

References

Jan 1, 1987·Annual Review of Physiology·R M Hochmuth, R E Waugh
Jun 5, 1997·Nature·K Simons, E Ikonen
Nov 14, 1998·The American Journal of Physiology·R S SpragueA J Lonigro
Mar 17, 1999·Journal of Biochemical and Biophysical Methods·D M Amundson, M Zhou
Oct 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·A RadhakrishnanH M McConnell
Nov 19, 2003·Cell·Sean Munro
Aug 4, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yvonne LangeTheodore L Steck
Nov 26, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Martin FariasEric O Feigl
Feb 25, 2005·Lipids·Ole G Mouritsen, Martin J Zuckermann
Dec 2, 2005·Nature·Frederick R Maxfield, Ira Tabas
Feb 3, 2007·Biochemistry·Yvonne LangeTheodore L Steck
Sep 22, 2007·Current Opinion in Lipidology·Frank D KolodgieRenu Virmani
May 20, 2008·Cardiovascular Therapeutics·Genovefa D KolovouDennis V Cokkinos
Oct 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jiandi WanHoward A Stone
Apr 15, 2009·Physiology·Mary L EllsworthRandy S Sprague
Oct 20, 2009·Cardiovascular Drugs and Therapy·Dimitrios N TziakasStavros Konstantinides
Mar 23, 2010·Microvascular Research·Alison M ForsythHoward A Stone
Jun 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Alison M ForsythHoward A Stone

❮ Previous
Next ❯

Citations

Jan 22, 2013·American Journal of Physiology. Heart and Circulatory Physiology·K M ClappA H Stephenson
Mar 8, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Denisa MarginaMihaela Ilie
Oct 20, 2015·Journal of Biomechanics·Kerryn MatthewsHongshen Ma
Aug 12, 2015·Purinergic Signalling·Geoffrey Burnstock
Jun 15, 2014·Clinical Hemorheology and Microcirculation·Marijke GrauWilhelm Bloch
Aug 7, 2014·Blood·Jacek SikoraRyszard Grygorczyk
Oct 28, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Gamaleldin I HarisaMohamed M Badran
Apr 18, 2018·Clinical Hemorheology and Microcirculation·Jean-Frédéric BrunEric Raynaud de Mauverger
Nov 24, 2016·Toxicologic Pathology·Lila RamaiahDaniela Ennulat
Feb 11, 2020·Biomechanics and Modeling in Mechanobiology·Robert J Asaro, Qiang Zhu
Mar 1, 2017·Current Atherosclerosis Reports·Mario da Silva Garrote-FilhoNilson Penha-Silva
Mar 16, 2018·Biomedical Optics Express·Vahid Sheikh-HasaniSeyed Nader Seyed Reihani
Dec 6, 2019·Frontiers in Physiology·Timothy J McMahon
Feb 17, 2021·Journal of Cellular and Molecular Medicine·Maria Aparecida KnychalaNilson Penha-Silva
Apr 1, 2021·Free Radical Biology & Medicine·Ali MahdiJohn Pernow
Nov 27, 2021·Cardiovascular & Hematological Disorders Drug Targets·Charalampos PapadopoulosKonstantinos Anagnostopoulos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.