The effects of METhotrexate therapy on the physical capacity of patients with ISchemic heart failure: a randomized double-blind, placebo-controlled trial (METIS trial)

Journal of Cardiac Failure
Daniel Medeiros MoreiraCarlos Antônio Mascia Gottschall

Abstract

The cytokine hypothesis suggests that there is an association between chronic heart failure (CHF) and inflammation. Methotrexate could improve CHF patients' clinical status, especially those with ischemic etiology. METIS is a randomized, double-blinded trial studying 50 patients with ischemic CHF given methotrexate (7.5mg) or placebo, plus folic acid (5mg), for 12 weeks. The primary end point was the difference in 6-minute walk test (6MWT) distance before and after treatment. We also evaluated functional class (NYHA), Short-Form 36 protocol quality of life, C-reactive protein (CRP), incidence of adverse effects, and the combined incidence of death, myocardial infarction, stroke, hospitalization, and need for myocardial revascularization. There was no significant difference between groups in distance covered in the 6MWT: the methotrexate group improved by 24.5+/-39.5m, the placebo group by 21.3+/-43.7m (P=.80). The NYHA scores improved in 66.7% of the methotrexate group patients and in 50.0% of the placebo group (P=.2). SF-36 scores indicated improved mental health in the placebo group. There were no significant differences in CRP levels, the combined outcome, or adverse events. These results show that the methotrexate group ten...Continue Reading

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References

Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·B N CronsteinR I Levin
Sep 1, 1996·Journal of Cardiac Failure·Y SetaD L Mann
Feb 7, 2003·Arthritis and Rheumatism·Gideon NesherShoshana Zevin
Mar 17, 2004·Heart·Stefan D Anker, Stephan von Haehling
Apr 16, 2004·Journal of Cardiovascular Pharmacology·Hiroshi AsanumaMasafumi Kitakaze
Jun 16, 2005·Archives of Internal Medicine·Fernando Rodríguez-ArtalejoManuel Conde Herrera
Jul 4, 2006·Journal of the American College of Cardiology·Andrea PassantinoDomenico Scrutinio
Feb 20, 2007·American Journal of Physiology. Heart and Circulatory Physiology·David K GloverGeorge A Beller
Dec 19, 2007·Circulation·Wayne RosamondUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Jan 30, 2008·Journal of Cardiac Failure·Ayman A El-Menyar
Mar 8, 2008·Arthritis Research & Therapy·Antonio NaranjoUNKNOWN QUEST-RA Group

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Citations

Aug 2, 2012·Therapeutic Advances in Musculoskeletal Disease·Jonathan L Marks, Christopher J Edwards
Nov 6, 2014·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Daniel Medeiros MoreiraCarlos Antonio Mascia Gottschall
Mar 23, 2017·Journal of Cardiovascular Pharmacology and Therapeutics·Daniel Medeiros MoreiraCarlos Antonio Mascia Gottschall
Jun 14, 2017·International Journal of Molecular Sciences·Megan YuYu-Min Kuo
Feb 6, 2018·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Sara RadenovicHans-Dirk Düngen
Jun 25, 2016·Circulation Research·Sarah A Dick, Slava Epelman
Mar 31, 2015·Circulation Research·Douglas L Mann
Feb 5, 2019·Herz·C Riehle, J Bauersachs
Jan 8, 2014·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Enas A S AttiaManal H El Hamamsy
May 29, 2016·Journal of Basic and Clinical Physiology and Pharmacology·Jyoti M Benni, Paragouda A Patil
Apr 23, 2017·Current Atherosclerosis Reports·Lily F ShiraziJawahar L Mehta
Feb 23, 2020·Journal of Cardiovascular Translational Research·Juli Halacoglu, Leticia A Shea
Jan 24, 2020·Nature Reviews. Cardiology·Luigi AdamoDouglas L Mann
Jan 13, 2015·Expert Review of Cardiovascular Therapy·Kitty HuynhSheryl L Chow
Feb 23, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Tian X ZhaoZiad Mallat
May 15, 2019·International Journal of Molecular Sciences·Diana Michels da SilvaTobias Graf
Nov 11, 2019·Heart Failure Reviews·Mieczysław DutkaMichał Ćwiertnia
Nov 21, 2018·Biology·Daniel P Jones, Jyoti Patel
Aug 17, 2019·Frontiers in Cardiovascular Medicine·Sinead A O'RourkeMichael G Monaghan
Mar 21, 2020·Journal of the American College of Cardiology·Sean P MurphyJames L Januzzi
Jun 26, 2013·Journal of Chemical Information and Modeling·Mahesh Kumar Teli, Rajanikant G K

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