The effects of methylmercury on endogenous dopamine efflux from mouse striatal slices

Toxicology Letters
B E Kalisch, W J Racz

Abstract

The present study investigated the effects of in vitro methylmercury (MeHg) exposure on endogenous dopamine (DA) efflux from mouse striatal slices. MeHg produced a concentration-dependent increase in the spontaneous efflux of DA which was independent of the availability of Ca2+ in the superfusion medium. The Ca(2+)-dependent K(+)-evoked release of DA was significantly enhanced by 50 and 100 microM MeHg. This increase could not be solely accounted for by the MeHg-induced increased in spontaneous DA efflux. The K(+)-stimulated efflux of DA was enhanced by MeHg in both the presence and absence of Ca2+ in the superfusion medium, suggesting that under depolarizing conditions, DA efflux induced by MeHg has a Ca(2+)-independent component. The alterations in DA efflux occurred at concentrations of MeHg previously found in the CNS of animals exhibiting symptoms of MeHg intoxication suggesting that alterations in DA neurotransmission in the striatum may contribute to the symptoms of MeHg toxicity.

References

Oct 1, 1979·Chemico-biological Interactions·G G Berg, E F Miles
Dec 1, 1992·Journal of Neuroscience Methods·A ElverforsH Nissbrandt
Feb 1, 1990·Toxicology and Applied Pharmacology·M F HareI A Michaelson
Mar 30, 1987·Toxicology and Applied Pharmacology·H Komulainen, S C Bondy
Jul 1, 1989·Toxicology and Applied Pharmacology·D J MinnemaR D Greenland
Feb 1, 1988·Canadian Journal of Physiology and Pharmacology·D W Clow, K Jhamandas
Jul 1, 1982·Canadian Journal of Physiology and Pharmacology·W J Racz, L J Vandewater
Jun 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·W D Atchison, M F Hare
Jul 1, 2006·The AAPS Journal·Evan L RiddleGlen R Hanson
Jan 1, 1987·Toxicology in Vitro : an International Journal Published in Association with BIBRA·K SaijohK Sumino

❮ Previous
Next ❯

Citations

Feb 22, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Chelsea T TiernanKeith J Lookingland
May 26, 2009·Neurotoxicology and Teratology·Anne DreiemRichard F Seegal
Jan 21, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Chelsea T TiernanKeith J Lookingland
Oct 30, 2016·Environmental Toxicology and Chemistry·Kristin BridgesAaron Roberts
Aug 24, 2007·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L R F FaroR Durán

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.