The effects of methylphenidate on novel object exploration in weanling and periadolescent rats

Annals of the New York Academy of Sciences
Charles J HeyserJennifer S Ferris

Abstract

Methylphenidate (Ritalin) is used in the treatment of attention-deficit hyperactivity disorder. Surprisingly, little research has been conducted on the effects of methylphenidate during early development. Therefore, the present study was conducted to examine the effects of methylphenidate on object exploration in developing rats. Male and female weanling (21-day-old) and periadolescent (34-day-old) Sprague-Dawley rats were tested after acute or chronic treatment with methylphenidate. In weanling rats, chronic methylphenidate (5.0 mg/kg) increased locomotor activity and disrupted novel object exploration. In periadolescent rats, methylphenidate disrupted exploration of the novel object, but had no effect on locomotor activity at any dose tested. Periadolescent rats appear to be less sensitive to methylphenidate-induced changes in activity compared to weanling animals, whereas methylphenidate disrupted novel object exploration in both ages. Our results suggest that methylphenidate may alter recognition memory and/or reactivity to or preference for novelty.

References

Nov 1, 1988·Behavioural Brain Research·A Ennaceur, J Delacour
Nov 7, 1998·Brain Research. Developmental Brain Research·C A BolanosD Jackson
May 19, 2000·Neuroscience and Biobehavioral Reviews·L P Spear
Oct 30, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·C L BrandonF J White
Dec 4, 2001·Nature Neuroscience·Susan L AndersenWilliam A Carlezon
May 7, 2003·Neuroscience and Biobehavioral Reviews·Giovanni LaviolaWalter Adriani
Dec 1, 1997·Behavioural Processes·R N Hughes

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Citations

May 17, 2008·Psychopharmacology·Leigh C P BotlyPaul J Fletcher
Mar 10, 2010·Journal of Neural Transmission·Karin M GomesJoão Quevedo
Jan 23, 2016·Behavioural Brain Research·Alex R De SerranoF Helen Rodd
Apr 6, 2011·Neuroscience Letters·José A BethancourtGabrielle B Britton
Aug 10, 2010·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Fabio FumagalliMarco Andrea Riva
Aug 28, 2007·Journal of Neuroscience Methods·Janelle M SilversRosemarie M Booze
Jun 5, 2007·Neurobiology of Learning and Memory·Denise LeBlanc-Duchin, Harald K Taukulis
Jan 3, 2007·Neuroscience and Biobehavioral Reviews·Robert N Hughes
May 4, 2012·Developmental Psychobiology·Charles J Heyser, Jennifer S Ferris
Apr 30, 2005·Trends in Pharmacological Sciences·Susan L Andersen
Jul 15, 2015·Journal of Molecular Neuroscience : MN·Yaarit Simchon TenenbaumMoshe Rehavi
Nov 4, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Sabrina MioranzzaLisiane O Porciúncula
Feb 3, 2015·Pharmacology, Biochemistry, and Behavior·Panayotis K ThanosNora D Volkow
Aug 3, 2013·Behavioural Brain Research·Charles J HeyserAllen A Fienberg
Mar 29, 2011·The International Journal of Neuropsychopharmacology·Gabrielle B Britton
Jan 1, 2009·Neurobiology of Learning and Memory·Denise LeBlanc-Duchin, Harald K Taukulis
Apr 8, 2020·Journal of Psychopharmacology·Patrícia Maidana MiguelLenir Orlandi Pereira
Jul 17, 2016·Learning & Memory·Corinna RoschlauWolfgang Hauber
Apr 13, 2017·Frontiers in Behavioral Neuroscience·Lisa S RobisonPanayotis K Thanos
Sep 22, 2018·Journal of Neural Transmission·Emily CariasPanayotis K Thanos
Dec 12, 2020·Neurobiology of Learning and Memory·Arely Cruz-SanchezMaithe Arruda-Carvalho

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