PMID: 6160433Dec 1, 1980Paper

The effects of microiontophoretically applied capsaicin and substance P on single neurones in the rat and cat brain

Neuroscience Letters
T E Salt, R G Hill

Abstract

Microiontophoretically applied capsaicin (10-480 nA) excited neurones in trigeminal nucleus caudalis (ntV) or potentiated their amino acid-induced excitation (20 of 23 neurones); inhibited one neurone; and had no effect on 2 neurones. Substance P (SP) excited 8 of 9 ntV neurones, and of these 8 neurones 6 were excited, one was depressed, and one was unaffected by capsaicin. Of 13 cerebellar neurones, 5 were depressed by capsaicin and 8 were unaffected. SP excited 3 of 5 cerebellar neurones. It is concluded that the excitatory action of capsaicin in ntV may be due to release of SP from neuronal structures and that the lack of excitatory effects seen in the cerebellum may reflect the absence of SP-containing neurones in this structure.

Citations

Jan 1, 1985·Cell and Tissue Research·D C TaylorJ Szolcsányi
May 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·R GamseJ M Lundberg
Jan 1, 1983·Pharmacology, Biochemistry, and Behavior·R J BodnarG Nilaver
Jan 1, 1984·Pharmacology & Therapeutics·T Hori
Dec 1, 1984·Brain Research·L C Russell, K J Burchiel
Oct 23, 1989·Neuroscience Letters·M Takaki, S Nakayama
Jan 1, 1986·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·L ErdélyiM Nedeljkovic
May 27, 2016·Temperature : Multidisciplinary Biomedical Journal·János Szolcsányi
Nov 10, 2006·Molecular Pain·Hendrik W SteenlandMin Zhuo
Sep 1, 1982·Acta Physiologica Scandinavica·M YanagisawaS Rosell
Feb 1, 1983·Pain·M Fitzgerald
Oct 1, 1982·Critical Reviews in Toxicology·Y MonsereenusornP D Pezalla

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