The effects of micronutrient deficiencies on bacterial species from the human gut microbiota

Science Translational Medicine
Matthew C HibberdJeffrey I Gordon

Abstract

Vitamin and mineral (micronutrient) deficiencies afflict 2 billion people. Although the impact of these imbalances on host biology has been studied extensively, much less is known about their effects on the gut microbiota of developing or adult humans. Therefore, we established a community of cultured, sequenced human gut-derived bacterial species in gnotobiotic mice and fed the animals a defined micronutrient-sufficient diet, followed by a derivative diet devoid of vitamin A, folate, iron, or zinc, followed by return to the sufficient diet. Acute vitamin A deficiency had the largest effect on bacterial community structure and metatranscriptome, with Bacteroides vulgatus, a prominent responder, increasing its abundance in the absence of vitamin A. Applying retinol selection to a library of 30,300 B. vulgatus transposon mutants revealed that disruption of acrR abrogated retinol sensitivity. Genetic complementation studies, microbial RNA sequencing, and transcription factor-binding assays disclosed that AcrR is a repressor of an adjacent AcrAB-TolC efflux system. Retinol efflux measurements in wild-type and acrR-mutant strains plus treatment with a pharmacologic inhibitor of the efflux system revealed that AcrAB-TolC is a determi...Continue Reading

References

May 1, 1971·The Proceedings of the Nutrition Society·R H Girdwood
Jun 1, 1972·The Journal of Nutrition·J C SmithJ A Halsted
Feb 7, 1969·Science·J G BieriW E Rogers
Oct 1, 1965·The Journal of Nutrition·B S ReddyB S Wostmann
Aug 1, 1994·The Journal of Nutrition·B A Underwood
Oct 13, 1993·Biochimica Et Biophysica Acta·E H Harrison
Apr 1, 1997·Journal of Bacteriology·D G ThanassiH Nikaido
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·H I Zgurskaya, H Nikaido
Nov 16, 2002·BMJ : British Medical Journal·Tarun Gera, H P S Sachdev
Jun 3, 2004·Genome Research·Gavin E CrooksSteven E Brenner
Jan 22, 2008·Lancet·Robert E BlackUNKNOWN Maternal and Child Undernutrition Study Group
Mar 6, 2009·Genome Biology·Ben LangmeadSteven L Salzberg
May 29, 2009·BMC Bioinformatics·Weijun LuoPeter J Woolf
Jun 16, 2009·Journal of Proteome Research·Ze-Qiang MaDavid L Tabb
Sep 15, 2009·Cell Host & Microbe·Andrew L GoodmanJeffrey I Gordon
Apr 13, 2010·Nature Methods·J Gregory CaporasoRob Knight
May 7, 2010·The Journal of Biological Chemistry·Federico E ReyJeffrey I Gordon
Mar 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Andrew L GoodmanJeffrey I Gordon
May 21, 2011·Science·Jeremiah J FaithJeffrey I Gordon
Oct 28, 2011·Science Translational Medicine·Nathan P McNultyJeffrey I Gordon
Mar 30, 2012·Omics : a Journal of Integrative Biology·Guangchuang YuQing-Yu He
Jul 21, 2012·Bioinformatics·Tom TavernerRichard D Smith
Nov 10, 2012·Science·Hal Drakesmith, Andrew M Prentice
Dec 3, 2013·Nucleic Acids Research·Ross OverbeekRick Stevens
Feb 26, 2014·BMC Public Health·Rehana A SalamZulfiqar A Bhutta
Apr 22, 2014·Nature·Dijun DuBen F Luisi
Jun 5, 2014·Nature·Sathish SubramanianJeffrey I Gordon
Dec 18, 2014·Genome Biology·Michael I LoveSimon Anders

❮ Previous
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Citations

Apr 5, 2019·Critical Reviews in Food Science and Nutrition·Lisa Miclotte, Tom Van de Wiele
Mar 26, 2019·Current Alzheimer Research·Kristina Endres
Aug 17, 2018·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jordan E BisanzPeter J Turnbaugh
Feb 8, 2018·Food & Function·T RequenaC Peláez
Dec 17, 2019·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Sunmin ParkDa Sol Kim
Dec 28, 2019·Nucleic Acids Research·Yiming HuangHarris H Wang
Jan 23, 2020·Nutrients·Daniela CiobârcăGianina Crișan
Jun 7, 2019·PLoS Pathogens·Namrata Iyer, Shipra Vaishnava
Sep 29, 2018·Nature Reviews. Gastroenterology & Hepatology·Niv ZmoraEran Elinav
Jan 24, 2020·Proceedings of the National Academy of Sciences of the United States of America·Lihui FengJeffrey I Gordon
Jul 28, 2020·Antioxidants·Helena Tiekou LorinczovaMohammed Gulrez Zariwala
Nov 28, 2017·The British Journal of Nutrition·Ruairi C RobertsonCatherine Stanton
May 5, 2018·Protein & Cell·Zeneng Wang, Yongzhong Zhao
Jul 8, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Arne Astrup, Susanne Bügel
Mar 16, 2019·Frontiers in Microbiology·Lu XiaoJie Chen
Dec 21, 2019·Nature Communications·Katharina V SchulzeNeil A Hanchard
Sep 20, 2017·Microbial Biotechnology·Cristal ZuñigaKarsten Zengler
Oct 3, 2017·Frontiers in Neuroscience·John R KellyTimothy G Dinan
Mar 15, 2019·Microbiology and Molecular Biology Reviews : MMBR·Janneke ElzingaHauke Smidt
Jul 6, 2019·Frontiers in Microbiology·Dmitry A RodionovAndrei L Osterman
Jun 21, 2019·Nutritional Neuroscience·Nalan Hakime Nogay, Marcia Nahikian-Nelms
Feb 18, 2020·Psychopharmacology·Beatriz Peñalver BernabéJack A Gilbert
Sep 28, 2018·Frontiers in Microbiology·J Philip KarlJason W Soares
May 16, 2019·Critical Reviews in Biochemistry and Molecular Biology·Margherita T CantornaJuhi Arora
Nov 26, 2019·European Journal of Pediatrics·Perran BoranDuy M Dinh
Aug 8, 2018·Nutrients·Leila Abdelhamid, Xin M Luo
Mar 31, 2018·Nature Reviews. Microbiology·Karsten Zengler, Livia S Zaramela
Sep 4, 2019·Nature Biotechnology·Tomasz WilmanskiNathan D Price
Oct 13, 2020·Critical Reviews in Food Science and Nutrition·Jianmin WuXi Ma
Nov 21, 2020·Clinical Science·Zhiyuan GuanChunli Song
Mar 12, 2020·Clinical Immunology : the Official Journal of the Clinical Immunology Society·John Michael S SanchezRobert S Fujinami
Feb 16, 2021·Journal of Lipid Research·Maryam HonarbakhshLoredana Quadro
Oct 23, 2020·Food Science and Biotechnology·Bryna RackerbySi Hong Park
Dec 31, 2020·Microorganisms·Agnieszka ZawadaIwona Krela-Kaźmierczak
Jan 29, 2021·Frontiers in Immunology·Shireen Mohammad, Christoph Thiemermann

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