PMID: 8970820Sep 15, 1996Paper

The effects of moderate and low levels of acoustic overstimulation on stereocilia and their tip links in the guinea pig

Hearing Research
J A Clark, J O Pickles

Abstract

Guinea pigs were exposed to pure tones of 10 kHz at intensities between 98 and 115 dB SPL for 5-30 min, to produce varying degrees of acoustic trauma. Changes in auditory thresholds were measured electrophysiologically, and the animals were immediately fixed for scanning electron microscopy. Correlation between morphological changes to the hair bundle and losses in threshold, showed that with the smallest degrees of trauma (98 dB SPL for 15 min, mean maximum threshold loss of 22 dB), damage was confined to a small stretch of inner hair cells (IHC), with only subtle changes to the stereocilia of the outer hair cells (OHC). At exposure intensities greater than 102 dB SPL (duration: 15 min) the IHC stereocilia in the centre of the lesion were always substantially disarrayed. Substantial damage to the OHC bundles was seen only with exposures above 110 dB SPL (duration: > or = 5 min), producing threshold losses of 50 dB or more. Tip links were lost only where the stereocilia were disarrayed. It is concluded that the tip links are not the most vulnerable components of the cochlear hair cell, but that relatively low levels of acoustic stimulation can cause significant damage to the stereociliary bundle of the IHCs.

References

Jul 1, 1992·Trends in Neurosciences·J O Pickles, D P Corey
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Citations

Mar 3, 2007·Journal of the Association for Research in Otolaryngology : JARO·Glen M WatsonPatricia Mire
May 14, 2011·Journal of the Association for Research in Otolaryngology : JARO·Christopher C LiuJohn S Oghalai
Aug 15, 2000·Neuroscience and Biobehavioral Reviews·K C Ross, J R Coleman
Jan 15, 2002·Hearing Research·Patricia Mire, Jason Nasse
May 7, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Ramazan OcalanSeren Gulsen Gurgen
Nov 27, 2010·Hearing Research·Kevin K OhlemillerAmanda J Ortmann
Sep 30, 2004·Biophysical Journal·Brett ShoelsonRichard S Chadwick
Dec 17, 2008·International Journal of Audiology·Shaum P Bhagat, Anne M Davis
Jan 13, 2004·The Journal of the Acoustical Society of America·Mark E ChertoffJeffery T Lichtenhan
Aug 5, 2016·The Journal of Experimental Biology·Pei-Ciao TangGlen M Watson
Jul 24, 2001·Audiology : Official Organ of the International Society of Audiology·M KossowskiP Avan
Aug 12, 2014·Current Opinion in Otolaryngology & Head and Neck Surgery·Kevin W Christie, Daniel F Eberl
Dec 5, 2019·The Journal of the Acoustical Society of America·Aryn M KamererDaniel M Rasetshwane
May 3, 2020·Proceedings of the National Academy of Sciences of the United States of America·Woongsu HanChul Hoon Kim
Aug 13, 1999·Journal of Neurophysiology·S G Kujawa, M C Liberman
Oct 20, 2006·The Journal of Experimental Biology·Michael E SmithArthur N Popper

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