The effects of mometasone furoate and strontium chloride in a rat model of allergic rhinitis.

Ear, Nose, & Throat Journal
Emine Elif AltuntaşMelih Akyol

Abstract

Neurogenic inflammation plays a role in the pathophysiology of allergic rhinitis. Highly effective in reducing the sensory irritation caused by some substances, strontium salts directly affect C-type nerve fibers. The aim of this study was to compare the efficacy of mometasone furoate and strontium chloride on early-phase symptoms in a rat model of allergic rhinitis. Wistar albino rats (n = 24) were randomly divided into three groups: the mometasone group, receiving 1 μg mometasone furoate (2 µl/site); the strontium 3% group, receiving 3% strontium chloride (2 μl/site); and the strontium 5% group, receiving 5% strontium chloride (2 μl/site). To induce significant nasal symptoms of allergic rhinitis, 5 µmol of histamine dihydrochloride (HDC) (2 µl/site) was administered. Symptoms of allergic rhinitis were recorded as frequencies of sneezing and nasal rubbing during a 15-minute interval. On days 1 and 2, respectively, 0.9% sodium chloride (NaCl) (2 μl/site to each nasal cavity) and HDC were administered in all of the study groups. On days 3 and 4, the study drugs were administered 10 and 30 minutes before the administration of HDC. On day 5, the study drugs were administered 10 minutes after the administration of HDC. The results...Continue Reading

References

Apr 23, 2005·Nature·Philip Ball
Apr 20, 2016·Headache·Jason Roberts
Dec 6, 2016·Annals of Internal Medicine·David Moher, Ester Moher

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Citations

May 13, 2020·International Forum of Allergy & Rhinology·Robert T SataloffD Bradley Welling
May 30, 2020·The Laryngoscope·Robert T SataloffD Bradley Welling
Apr 10, 2020·American Journal of Rhinology & Allergy·Robert T SataloffD Bradley Welling
Mar 3, 2020·The Annals of Otology, Rhinology, and Laryngology·Robert T SataloffD Bradley Welling
Mar 11, 2020·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·Robert T SataloffD Bradley Welling
Jul 1, 2020·The Journal of Laryngology and Otology·Robert T SataloffD Bradley Welling
Mar 18, 2020·Ear, Nose, & Throat Journal·Robert T SataloffD Bradley Welling
Dec 19, 2019·Ear, Nose, & Throat Journal·Rick Chandra
Dec 2, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Robert T SataloffD Bradley Welling
Apr 12, 2020·Journal of Voice : Official Journal of the Voice Foundation·Robert T SataloffD Bradley Welling
May 10, 2021·Auris, Nasus, Larynx·Asli Cakir CetinYesim Tuncok

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