The Effects of Momordica balsamina Methanolic Extract on Kidney Function in STZ-Induced Diabetic Rats: Effects on Selected Metabolic Markers

Journal of Diabetes Research
Anelisiwe SibotoPhikelelani Siphosethu Ngubane

Abstract

Studies suggest that Momordica balsamina (intshungu) possesses hypoglycaemic effects. The effects of Momordica balsamina on diabetic complications such as DN, however, have not been established. Accordingly, this study seeks to investigate the effects of M. balsamina on kidney function in STZ-induced diabetic rats. Methanolic extracts (ME) of M. balsamina's leaves were used in this study. Short-term effects of M. balsamina methanolic extract on kidney function and MAP were studied in STZ-induced diabetic rats treated twice daily with M. balsamina methanolic extract (250 mg/kg), insulin (175 μg/kg, s.c.), and metformin (500 mg/kg) for 5 weeks. M. balsamina methanolic extract significantly increased Na+ excretion outputs in STZ-induced diabetic rats by comparison to STZ-diabetic control rats. M. balsamina methanolic extract significantly increased GFR in STZ-diabetic rats with a concomitant decrease in creatinine concentration and also reduced kidney-to-body ratio, albumin excretion rate (AER), and albumin creatinine ratio (ACR). M. balsamina methanolic extract significantly reduced MAP in STZ-diabetic animals by comparison with STZ-diabetic control animals. These results suggest that M. balsamina methanolic extract not only lowe...Continue Reading

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Citations

Dec 13, 2019·Journal of Diabetes Research·Charity M BaloyiPhikelelani S Ngubane
Dec 12, 2018·BioMed Research International·Anush AghajanyanArmen Trchounian
Feb 9, 2021·Journal of Diabetes and Metabolic Disorders·Pouya SalahiMasoud Alirezaei
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mohamed Faisal LutfiMansour Alsharidah
Jul 15, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Yu LiuJian-Da Zhou
May 18, 2020·Current Diabetes Reviews·Neeraj ChoudharyAshish Suttee

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Methods Mentioned

BETA
glycosylation
MDA
ELISA

Software Mentioned

GraphPad Prism
GraphPad
InStat

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