The effects of morphine on the accumulation of homovanillic and 5-hydroxyindoleacetic acids in the choroid plexus of rats

British Journal of Pharmacology
J T Huang, I J Wajda

Abstract

1 Choroid plexus obtained from the lateral ventricles of the rat actively accumulated homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA). 2 Morphine 5 X 10(-6) M to 5 X 10(-4)M potentiated 5-HIAA accumulation but did not affect HVA accumulation. Levorphanol and dextorphan had little effect. 3 Naloxone at high concentrations inhibited both HVA and 5-HIAA accumulation. 4 Glutamic acid, glycine, and arginine also decreased 5-HIAA accumulation, but lysine, tryptophan, and aspartic acid had no effect. 5 Probenecid, naloxone, arginine, glycine, and tryptophan blocked the increase of 5-HIAA accumulation induced by morphine. 6 Acute or chronic morphine treatment did not increase the accumulation of 5-HIAA. 7 These results suggest that the increase of 5-HIAA or HVA in brain by morphine is not due to the inhibition of the elimination of these metabolites from the choroid plexus.

References

May 1, 1976·The Journal of Pharmacy and Pharmacology·M F Sugrue, I McIndewar
Mar 1, 1975·Neuropharmacology·J T Huang, A E Takemori
Mar 1, 1975·British Journal of Pharmacology·B M CoxJ Willis
Jan 1, 1974·Annual Review of Biochemistry·A E Takemori
Dec 1, 1974·European Journal of Pharmacology·I Goodlet, M F Sugrue
Dec 15, 1974·Experientia·P Stern, M Stern
Jun 1, 1974·European Journal of Pharmacology·H KoyuncuoğluL Eroğlu
Mar 1, 1971·The American Journal of Physiology·H F Cserr, D H VanDyke

Related Concepts

Metazoa
Structure of Choroid Plexus
Drug Interactions
Homovanillic Acid
Hydroxyindoleacetic Acid
Morphinans
Morphine Sulfate (2: 1), Pentahydrate
Phenylacetic Acids
Pro-Cid
Rats, Laboratory

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