The effects of naloxone administered into the periaqueductal gray on shock-elicited freezing behavior in the rat

Behavioral and Neural Biology
G D Hammer, B S Kapp

Abstract

Freezing behavior that occurs following footshock was found to increase in rats in which naloxone was injected into the ventrolateral region of the mesencephalic periaqueductal gray (PAG) area of the brain prior to footshock administration. Since naloxone administered into the ventrolateral region of the PAG induced minimal freezing in rats which did not receive footshock, the results suggest that the effect of naloxone on shock-induced freezing is not due to a nonspecific decrease in motor activity. Naloxone had no effect on freezing when injected into the dorsolateral region of the PAG. The data are consistent with the theory that conditioned fear induces opioid mediated analgesia, and that the ventrolateral region of the PAG is an important component of a pain-inhibitory system involved in this analgesia.

References

Aug 1, 1979·Journal of Comparative and Physiological Psychology·M S Fanselow, R C Bolles
Aug 15, 1978·Experimental Brain Research·D A Hopkins, G Holstege
Aug 1, 1978·Journal of Comparative and Physiological Psychology·T WerkaH Ursin

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Citations

Jun 29, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Kevin A ChaitoffAhmmed Ally
Nov 15, 2002·Brain Research Bulletin·Terence V Sewards, Mark A Sewards
Oct 4, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lori N Eidson, Anne Z Murphy
Jun 7, 2005·Neurobiology of Learning and Memory·Matthew J SandersMichael S Fanselow
Dec 24, 1990·Brain Research·F J Helmstetter, J Landeira-Fernandez
Nov 5, 2020·Behavioural Brain Research·J A StricklandM A McDannald

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