PMID: 3197Jan 1, 1976

The effects of narcotics on fetal acid base status

British Journal of Obstetrics and Gynaecology
A ChangC Wagstaff

Abstract

This paper reports two randomized control trials on the effects of nalorphine, pethidine, morphine and heroin on fetal and maternal acid base status. The drugs decreased pH and increased pCO2 in the mother, and decreased pH and base excess in the fetus. The changes in the fetus were independent of the changes in the mother. In equivalent dosages, nalorphine increased maternal pCO2 more than pethidine and morphine. The effects of heroin were found to be greater than that of other drugs, and we suggest that heroin should be avoided where the fetus is already at risk.

References

Jan 1, 1982·Neuroscience and Biobehavioral Reviews·I S ZagonE Zagon
Aug 1, 1982·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M RonZ Palti
Jun 6, 2018·The Cochrane Database of Systematic Reviews·Lesley A SmithAnna Cuthbert
Nov 11, 2010·Journal of Emergencies, Trauma, and Shock·Sukhwinder Kaur BajwaJasleen Kaur
Sep 9, 2010·The Cochrane Database of Systematic Reviews·Roz UllmanTherese Dowswell

Citations

Mar 1, 1975·British Journal of Obstetrics and Gynaecology·M HumphreyC Wood
Dec 1, 1967·The Journal of Pharmacy and Pharmacology·A H BeckettA S Virji
Dec 22, 1972·Nature·G H Gurtner, B Burns
Apr 1, 1973·The Journal of Obstetrics and Gynaecology of the British Commonwealth·C WoodH Benning
Nov 1, 1973·The Journal of Obstetrics and Gynaecology of the British Commonwealth·D HounslowA Chang
Apr 1, 1969·The Journal of Obstetrics and Gynaecology of the British Commonwealth·A J KrinsC Wood
Nov 1, 1971·The Journal of Obstetrics and Gynaecology of the British Commonwealth·L Jacobson, G Rooth
Oct 1, 1966·American Journal of Obstetrics and Gynecology·K Adamsons, I Joelsson
Oct 25, 1969·British Medical Journal·C K AngC Wood
Nov 1, 1965·Acta paediatrica Scandinavica·P Ranlov, O Siggaard-Andersen
Dec 1, 1965·British Journal of Anaesthesia·J S Crawford, S Rudofsky
Jun 1, 1953·American Journal of Obstetrics and Gynecology·J E ECKENHOFFL W FUNDERBURG
Jan 30, 1954·Journal of the American Medical Association·B E CAPPE, I M PALLIN
Apr 1, 1954·The Journal of Obstetrics and Gynaecology of the British Empire·J A CHALMERS, C J THORNBERRY
Feb 1, 1961·American Journal of Obstetrics and Gynecology·A E HELLEGERS, J J SCHRUEFER
Jan 1, 1962·Journal of Pharmaceutical Sciences·R F GAUTIERI, H P CIUCHTA
Aug 15, 1964·American Journal of Obstetrics and Gynecology·S M SHNIDER, F MOYA

Related Concepts

Fetal Structures
Entire Fetus
Base Excess Measurement
Heroin
Morphine Measurement
Meperidine
Narcotics
Meperidine Hydrochloride
Min-I-Jet Morphine Sulphate
Anion Gap

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