PMID: 3197Jan 1, 1976

The effects of narcotics on fetal acid base status

British Journal of Obstetrics and Gynaecology
A ChangC Wagstaff


This paper reports two randomized control trials on the effects of nalorphine, pethidine, morphine and heroin on fetal and maternal acid base status. The drugs decreased pH and increased pCO2 in the mother, and decreased pH and base excess in the fetus. The changes in the fetus were independent of the changes in the mother. In equivalent dosages, nalorphine increased maternal pCO2 more than pethidine and morphine. The effects of heroin were found to be greater than that of other drugs, and we suggest that heroin should be avoided where the fetus is already at risk.


Jan 1, 1982·Neuroscience and Biobehavioral Reviews·I S ZagonE Zagon
Aug 1, 1982·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M RonZ Palti
Jun 6, 2018·The Cochrane Database of Systematic Reviews·Lesley A SmithAnna Cuthbert
Nov 11, 2010·Journal of Emergencies, Trauma, and Shock·Sukhwinder Kaur BajwaJasleen Kaur
Sep 9, 2010·The Cochrane Database of Systematic Reviews·Roz UllmanTherese Dowswell


Mar 1, 1975·British Journal of Obstetrics and Gynaecology·M HumphreyC Wood
Dec 1, 1967·The Journal of Pharmacy and Pharmacology·A H BeckettA S Virji
Dec 22, 1972·Nature·G H Gurtner, B Burns
Apr 1, 1973·The Journal of Obstetrics and Gynaecology of the British Commonwealth·C WoodH Benning
Nov 1, 1973·The Journal of Obstetrics and Gynaecology of the British Commonwealth·D HounslowA Chang
Apr 1, 1969·The Journal of Obstetrics and Gynaecology of the British Commonwealth·A J KrinsC Wood
Nov 1, 1971·The Journal of Obstetrics and Gynaecology of the British Commonwealth·L Jacobson, G Rooth
Oct 1, 1966·American Journal of Obstetrics and Gynecology·K Adamsons, I Joelsson
Oct 25, 1969·British Medical Journal·C K AngC Wood
Nov 1, 1965·Acta paediatrica Scandinavica·P Ranlov, O Siggaard-Andersen
Dec 1, 1965·British Journal of Anaesthesia·J S Crawford, S Rudofsky
Jun 1, 1953·American Journal of Obstetrics and Gynecology·J E ECKENHOFFL W FUNDERBURG
Jan 30, 1954·Journal of the American Medical Association·B E CAPPE, I M PALLIN
Apr 1, 1954·The Journal of Obstetrics and Gynaecology of the British Empire·J A CHALMERS, C J THORNBERRY
Feb 1, 1961·American Journal of Obstetrics and Gynecology·A E HELLEGERS, J J SCHRUEFER
Jan 1, 1962·Journal of Pharmaceutical Sciences·R F GAUTIERI, H P CIUCHTA
Aug 15, 1964·American Journal of Obstetrics and Gynecology·S M SHNIDER, F MOYA

Related Concepts

Fetal Structures
Entire Fetus
Base Excess Measurement
Morphine Measurement
Meperidine Hydrochloride
Min-I-Jet Morphine Sulphate
Anion Gap

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.